CDD: a Conserved Domain Database for the functional annotation of proteins
| Autor: | Fu-Ping Lu, Carol DeWeese-Scott, John B. Anderson, James S. Song, Christopher J. Lanczycki, Zhaoxi Ke, Farideh Chitsaz, John D. Jackson, Mikhail Mullokandov, Roxanne A. Yamashita, Aron Marchler-Bauer, Marina V. Omelchenko, Chanjuan Zheng, Naigong Zhang, Noreen R. Gonzales, Marc Gwadz, Cynthia L. Robertson, Stephen H. Bryant, Gabriele H. Marchler, Jessica H. Fong, David I. Hurwitz, Lewis Y. Geer, Narmada Thanki, Renata C. Geer, Dachuan Zhang, Myra K. Derbyshire, Shennan Lu |
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| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Conserved Domain Database
Protein domain Proteins Domain model Computational biology Articles Biology Bioinformatics Models Biological Conserved sequence Domain (software engineering) Protein Structure Tertiary Entrez Annotation Protein Annotation Sequence Analysis Protein Genetics Amino Acid Sequence Databases Protein Conserved Sequence |
| Zdroj: | Nucleic Acids Research |
| ISSN: | 1362-4962 0305-1048 |
| Popis: | NCBI's Conserved Domain Database (CDD) is a resource for the annotation of protein sequences with the location of conserved domain footprints, and functional sites inferred from these footprints. CDD includes manually curated domain models that make use of protein 3D structure to refine domain models and provide insights into sequence/structure/function relationships. Manually curated models are organized hierarchically if they describe domain families that are clearly related by common descent. As CDD also imports domain family models from a variety of external sources, it is a partially redundant collection. To simplify protein annotation, redundant models and models describing homologous families are clustered into superfamilies. By default, domain footprints are annotated with the corresponding superfamily designation, on top of which specific annotation may indicate high-confidence assignment of family membership. Pre-computed domain annotation is available for proteins in the Entrez/Protein dataset, and a novel interface, Batch CD-Search, allows the computation and download of annotation for large sets of protein queries. CDD can be accessed via http://www.ncbi.nlm.nih.gov/Structure/cdd/cdd.shtml. |
| Databáze: | OpenAIRE |
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