Lipid organization of the plasma membrane
| Autor: | Tsjerk A. Wassenaar, Clement Arnarez, Floris J. van Eerden, Siewert J. Marrink, Xavier Periole, Manuel N. Melo, D. Peter Tieleman, Alex H. de Vries, Helgi I. Ingólfsson, Cesar A. Lopez |
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| Přispěvatelé: | Molecular Dynamics |
| Jazyk: | angličtina |
| Rok vydání: | 2014 |
| Předmět: |
0303 health sciences
Leaflet (botany) 010304 chemical physics Chemistry Cell Membrane General Chemistry Plasma Molecular Dynamics Simulation Lipids 01 natural sciences Biochemistry Catalysis Cell membrane 03 medical and health sciences Molecular dynamics Colloid and Surface Chemistry medicine.anatomical_structure Membrane 0103 physical sciences medicine Biophysics lipids (amino acids peptides and proteins) 030304 developmental biology |
| Zdroj: | Journal of the American Chemical Society, 136(41), 14554-14559. AMER CHEMICAL SOC |
| ISSN: | 0002-7863 |
| DOI: | 10.1021/ja507832e |
| Popis: | The detailed organization of cellular membranes remains rather elusive. Based on large-scale molecular dynamics simulations, we provide a high-resolution view of the lipid organization of a plasma membrane at an unprecedented level of complexity. Our plasma membrane model consists of 63 different lipid species, combining 14 types of headgroups and 11 types of tails asymmetrically distributed across the two leaflets, closely mimicking an idealized mammalian plasma membrane. We observe an enrichment of cholesterol in the outer leaflet and a general non-ideal lateral mixing of the different lipid species. Transient domains with liquid-ordered character form and disappear on the microsecond time scale. These domains are coupled across the two membrane leaflets. In the outer leaflet, distinct nanodomains consisting of gangliosides are observed. Phosphoinositides show preferential clustering in the inner leaflet. Our data provide a key view on the lateral organization of lipids in one of life's fundamental structures, the cell membrane. |
| Databáze: | OpenAIRE |
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