Klebsiella pneumoniae Sequence Type 11 from Companion Animals Bearing ArmA Methyltransferase, DHA-1 β-Lactamase, and QnrB4
| Autor: | Laura Carrilero, Stephanie Matrat, Daniel Thomas-Lopez, Laura Hidalgo, Alfonso Santos-Lopez, Gloria Santurde, Belen Gutierrez, Carmen Martin-Espada, Courage Kosi Setsoafia Saba, Cristina M. Ovejero, Andreas Hoefer, Mónica Suárez, Bruno Gonzalez-Zorn |
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| Rok vydání: | 2013 |
| Předmět: |
clone (Java method)
Methyltransferase Klebsiella pneumoniae Cat Diseases beta-Lactamases Microbiology Bacterial protein 03 medical and health sciences Dogs Plasmid Bacterial Proteins Mechanisms of Resistance Animals Humans Protein Isoforms Pharmacology (medical) Dog Diseases 030304 developmental biology Sequence (medicine) Pharmacology 0303 health sciences biology 030306 microbiology Methyltransferases biology.organism_classification Phenotype Virology Klebsiella Infections 3. Good health Infectious Diseases Spain Cats Multilocus sequence typing Veterinaria Multilocus Sequence Typing Plasmids |
| Zdroj: | Antimicrobial Agents and Chemotherapy. 57:4532-4534 |
| ISSN: | 1098-6596 0066-4804 |
| Popis: | Seven Klebsiella pneumoniae isolates from dogs and cats in Spain were found to be highly resistant to aminoglycosides, and ArmA methyltransferase was responsible for this phenotype. All isolates were typed by multilocus sequence typing (MLST) as ST11, a human epidemic clone reported worldwide and associated with, among others, OXA-48 and NDM carbapenemases. In the seven strains, armA was borne by an IncR plasmid, pB1025, of 50 kb. The isolates were found to coproduce DHA-1 and SHV-11 β-lactamases, as well as the QnrB4 resistance determinant. This first report of the ArmA methyltransferase in pets illustrates their importance as a reservoir for human multidrug-resistant K. pneumoniae . |
| Databáze: | OpenAIRE |
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