Identification and mapping of ten new potential insulators in the FXYD5-COX7A1 region of human chromosome 19q13.12
| Autor: | D. A. Didych, E. V. Snezhkov, S. B. Akopov, N. V. Skaptsova, Eugene D. Sverdlov, Lev G. Nikolaev |
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| Rok vydání: | 2009 |
| Předmět: |
Genetics
Membrane Glycoproteins Microfilament Proteins Chromosome Mapping General Medicine Biology Biochemistry Ion Channels Neoplasm Proteins Electron Transport Complex IV genomic DNA Functional mapping Chromosome 19 Humans Human genome Insulator Elements Enhancer Promoter Regions Genetic Gene Chromosomes Human Pair 19 Selection system |
| Zdroj: | Biochemistry. Biokhimiia. 74(7) |
| ISSN: | 1608-3040 |
| Popis: | A positive-negative selection system revealed 10 potential insulators able to block enhancer interaction with promoter in the 10(6) bp human chromosome 19 region between genes FXYD5 and COX7A1. Relative positions of insulators and genes are in accord with the hypothesis that insulators subdivide genomic DNA into independently regulated loop domains. |
| Databáze: | OpenAIRE |
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