Outcome of vein of Galen malformation presenting in the neonatal period
| Autor: | Julia K. Gunn-Charlton, Peter Mitchell, Alison Wray, Stephanie Malarbi, Alice C. Burnett, Rod W. Hunt, Amy Williams, Trisha M Prentice |
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| Rok vydání: | 2019 |
| Předmět: |
Male
Pediatrics medicine.medical_specialty Critical Illness Psychological intervention Neuroimaging Middle childhood 03 medical and health sciences 0302 clinical medicine Intensive Care Units Neonatal Intensive care medicine Humans 030212 general & internal medicine Endovascular treatment Vein Retrospective Studies business.industry Australia Infant Newborn Neuropsychology Retrospective cohort study Prognosis Single centre medicine.anatomical_structure Neurodevelopmental Disorders Vein of Galen Malformations Pediatrics Perinatology and Child Health Female business 030217 neurology & neurosurgery |
| Zdroj: | Archives of Disease in Childhood. 104:1064-1069 |
| ISSN: | 1468-2044 0003-9888 |
| DOI: | 10.1136/archdischild-2018-316495 |
| Popis: | ObjectiveVein of Galenaneurysmal malformation (VGAM) is a rare but important congenital malformation presenting to neonatal intensive care units (NICUs), and with a change from surgical to endovascular management, survival for this condition has improved. However, there is little reported about the medical management decisions of infants with this condition and the associated long-term neurodevelopmental outcomes. We aim to report a single centre experience of both acute treatment and long-term outcomes of VGAM for those infants admitted to our NICU soon after birth.DesignRetrospective cohort study over a 15-year period from 2001 to 2015 inclusive.SettingA quaternary NICU at The Royal Children’s Hospital, Melbourne, Australia.Participants24 newborn infants referred for management of VGAM. There were no eligibility criteria set for this study; all presenting infants were included.InterventionsNone.Main outcomes measuresClinical neuroimaging data were gathered. Surviving children were formally assessed with a battery of tests administered by a neuropsychologist and occupational therapist/physiotherapist at various ages across early to middle childhood.ResultsFifteen neonates with VGAM did not survive beyond their NICU admission. 10 of these were not offered endovascular intervention. Of the nine surviving infants, only one had a normal neurodevelopmental outcome.ConclusionsThe mortality of VGAM presenting in the neonatal period was high, and rates of normal neurodevelopmental outcome for survivors were low. These findings contribute to our understanding of which neonates should be treated and highlights the importance of providing clinical neurodevelopmental follow-up to survivors beyond their infant years. |
| Databáze: | OpenAIRE |
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