Topographic correlation and asymmetry analysis of ganglion cell layer thinning and the retinal nerve fiber layer with localized visual field defects

Autor: Juan Carlos González, Raúl Fernández, Soraya Fonseca, Andrea Cerveró, Elena Gándara, Alicia López-de-Eguileta, Alfonso Casado, Miguel A Gordo-Vega, Gema Pacheco
Rok vydání: 2019
Předmět:
Male
Retinal Ganglion Cells
Intraocular pressure
Eye Diseases
genetic structures
Posterior pole
Nerve fiber layer
Glaucoma
Diagnostic Radiology
chemistry.chemical_compound
Nerve Fibers
0302 clinical medicine
Animal Cells
Germany
Medicine and Health Sciences
Macula Lutea
Prospective Studies
Scotoma
Tomography
Neurons
Visual Impairments
Aged
80 and over
Multidisciplinary
Radiology and Imaging
Middle Aged
Visual field
medicine.anatomical_structure
Medicine
Female
Anatomy
Cellular Types
Tomography
Optical Coherence
Research Article
Optic disc
Adult
medicine.medical_specialty
Ganglion Cells
Adolescent
Imaging Techniques
Science
Ocular Anatomy
Optic Disk
Research and Analysis Methods
Optic Disc
Retina
03 medical and health sciences
Ocular System
Diagnostic Medicine
Ophthalmology
medicine
Humans
Ganglion cell layer
Intraocular Pressure
Aged
business.industry
Biology and Life Sciences
Retinal
Cell Biology
medicine.disease
eye diseases
ROC Curve
chemistry
Cellular Neuroscience
030221 ophthalmology & optometry
Eyes
Visual Field Tests
sense organs
Visual Fields
business
Head
030217 neurology & neurosurgery
Neuroscience
Zdroj: PLoS ONE
PLoS ONE, Vol 14, Iss 9, p e0222347 (2019)
ISSN: 1932-6203
DOI: 10.1371/journal.pone.0222347
Popis: PurposeTo evaluate the accuracy of the measurement of the ganglion cell layer (GCL) of the posterior pole analysis (PPA) software of the Spectralis spectral-domain (SD) optical coherence tomography (OCT) device (Heidelberg Engineering, Inc., Heidelberg, Germany), the asymmetry of paired GCL sectors, the total retinal thickness asymmetry (RTA), and the peripapillary retinal nerve fiber layer (pRNFL) test to discriminate between healthy, early and advanced glaucoma eyes.MethodsThree hundred eighteen eyes of 161 individuals with reliable visual fields (VF) were enrolled in this study. All participants were examined using the standard posterior pole and the pRNFL protocols of the Spectralis OCT device. VF impairment was graded in hemifields, and the GCL sectors were correlated with this damage. Thicknesses of each GCL, the GCL map deviation asymmetry and the pRNFL were compared between control and glaucomatous eyes. The area under the receiver operating characteristic curve (AUC) of these analyses was assessed.ResultsFourteen of the 16 sectors of the GCL and pRNFL were significantly thinner in eyes with glaucoma than in control eyes (p0.823, p0.708, pConclusionsAlthough 16 central sectors of the GCL observed with PPA showed good correlation with VF damage, the pRNFL and the GCL map deviation were more effective for discrimination of glaucomatous damage.
Databáze: OpenAIRE
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