Gene Expression Studies to Identify Significant Genes in AR, MTOR, MAPK Pathways and their Overlapping Regulatory Role in Prostate Cancer
Autor: | Nimisha Asati, Abhinav Mishra, Tiratha Raj Singh, Ankita Shukla |
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Jazyk: | angličtina |
Rok vydání: | 2019 |
Předmět: |
Male
Microarray MAP Kinase Signaling System pathways Computational biology Prostate cancer Gene expression mtor medicine Humans Gene Mechanistic target of rapamycin mapk Research Articles PI3K/AKT/mTOR pathway biology Microarray analysis techniques TOR Serine-Threonine Kinases Prostatic Neoplasms General Medicine medicine.disease prostate cancer Neoplasm Proteins Gene Expression Regulation Neoplastic Androgen receptor meta-analysis Receptors Androgen biology.protein Databases Nucleic Acid microarray TP248.13-248.65 ar Biotechnology |
Zdroj: | Journal of Integrative Bioinformatics, Vol 16, Iss 3, Pp 135-40 (2019) Journal of Integrative Bioinformatics |
ISSN: | 1613-4516 |
Popis: | Gene expression studies revealed a large degree of variability in gene expression patterns particularly in tissues even in genetically identical individuals. It helps to reveal the components majorly fluctuating during the disease condition. With the advent of gene expression studies many microarray studies have been conducted in prostate cancer, but the results have varied across different studies. To better understand the genetic and biological regulatory mechanisms of prostate cancer, we conducted a meta-analysis of three major pathways i.e. androgen receptor (AR), mechanistic target of rapamycin (mTOR) and Mitogen-Activated Protein Kinase (MAPK) on prostate cancer. Meta-analysis has been performed for the gene expression data for the human species that are exposed to prostate cancer. Twelve datasets comprising AR, mTOR, and MAPK pathways were taken for analysis, out of which thirteen potential biomarkers were identified through meta-analysis. These findings were compiled based upon the quantitative data analysis by using different tools. Also, various interconnections were found amongst the pathways in study. Our study suggests that the microarray analysis of the gene expression data and their pathway level connections allows detection of the potential predictors that can prove to be putative therapeutic targets with biological and functional significance in progression of prostate cancer. |
Databáze: | OpenAIRE |
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