Eosinophilia in Asthma Patients Is Protective Against Severe COVID-19 Illness
| Autor: | Sunit Jariwala, Golda Hudes, Elina Jerschow, Merhunisa Karagic, Manish Ramesh, David L. Rosenstreich, Denisa Ferastraoaru, Gabriele de Vos |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
HTN Hypertension TMPRSS2 Transmembrane protease serine 2 COPD Chronic obstructive pulmonary disease 03 medical and health sciences FEV1 Forced expiratory volume in 1 second 0302 clinical medicine SARS-CoV-2 Severe acute respiratory syndrome coronavirus-2 ED Emergency department Internal medicine ACE2 Angiotensin-converting enzyme 2 Eosinophilia medicine Immunology and Allergy Humans 030212 general & internal medicine Mortality Asthma Inflammation COPD COVID-19 Coronavirus disease 2019 AEC Absolute eosinophil count CHF Congestive heart failure biology ICS Inhaled corticosteroid business.industry CI Confidence interval SARS-CoV-2 Mortality rate C-reactive protein COVID-19 Odds ratio respiratory system medicine.disease ICD International Classification of Diseases CKD Chronic kidney disease 030228 respiratory system Heart failure biology.protein CRP C-reactive protein Original Article medicine.symptom CLG Clinical Looking Glass DM Diabetes business Kidney disease OR Odds ratio |
| Zdroj: | The Journal of Allergy and Clinical Immunology. in Practice The Journal of Allergy and Clinical Immunology: In Practice |
| ISSN: | 2213-2201 2213-2198 |
| Popis: | Background There is a paucity of information on coronavirus disease 2019 (COVID-19) outcomes in asthmatics. Objective To identify risk factors associated with admission and subsequent mortality among COVID-19–infected asthmatics. Methods Adults at our institution with a positive polymerase chain reaction for COVID-19 between March 14 and April 27, 2020, were retrospectively identified. Comorbidities, laboratory results, and mortality rates during hospitalization were recorded. Results In total, 737 of 951 (77.5%) asthma patients with COVID-19 were seen in the emergency department (ED), and 78.8% of these ED patients (581 of 737) were admitted. Individuals with previously measured mean absolute eosinophil counts (AEC) ≥150 cells/μL were less likely to be admitted (odds ratio [OR] = 0.46, 95% confidence interval [CI]: 0.21-0.98, P = .04), whereas concomitant heart failure (CHF), chronic kidney disease (CKD), and chronic obstructive pulmonary disease (COPD) were risk factors for admission. Hospitalized patients with asthma with peak hospital-measured AEC ≥150 cells/μL (n = 104) were less likely to die compared with those whose AEC remained |
| Databáze: | OpenAIRE |
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