Purinergic signaling in cognitive impairment and neuropsychiatric symptoms of Alzheimer's disease

Autor: Deidiane Elisa Ribeiro, Lyvia Lintzmaier Petiz, Talita Glaser, Ágatha Oliveira-Giacomelli, Roberta Andrejew, Fernando de Azevedo Ribeiro Saab, Milena da Silva Milanis, Henrique Correia Campos, Vanessa Fernandes Arnaud Sampaio, Sophia La Banca, Beatriz Monteiro Longo, Claudiana Lameu, Yong Tang, Rodrigo Ribeiro Resende, Sergio T. Ferreira, Henning Ulrich
Rok vydání: 2022
Předmět:
Zdroj: Neuropharmacology.
ISSN: 1873-7064
Popis: About 10 million new cases of dementia develop worldwide each year, of which up to 70% are attributable to Alzheimer's disease (AD). In addition to the widely known symptoms of memory loss and cognitive impairment, AD patients frequently develop non-cognitive symptoms, referred to as behavioral and psychological symptoms of dementia (BPSDs). Sleep disorders are often associated with AD, but mood alterations, notably depression and apathy, comprise the most frequent class of BPSDs. BPSDs negatively affect the lives of AD patients and their caregivers, and have a significant impact on public health systems and the economy. Because treatments currently available for AD are not disease-modifying and mainly aim to ameliorate some of the cognitive symptoms, elucidating the mechanisms underlying mood alterations and other BPSDs in AD may reveal novel avenues for progress in AD therapy. Purinergic signaling is implicated in the pathophysiology of several CNS disorders, such as AD, depression and sleep disorders. Here, we review recent findings indicating that purinergic receptors, mainly the A
Databáze: OpenAIRE
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