Combined experimental and computational approaches to study the regulatory elements in eukaryotic genes

Autor:	Nikolay A. Kolchanov, Elena V. Ignatieva, V. M. Merkulov, Viktor G. Levitsky, Dmitry Oshchepkov, E. A. Ananko, Gennady V. Vasiliev, Tatyana I. Merkulova, T. Charles Hodgman, Nataly V. Klimova
Rok vydání:	2007
Předmět:	Genetics Computational Biology Eukaryotic gene Experimental data Genome project Computational biology Biology Models Biological Genome DNA binding site Eukaryotic Cells Gene Expression Regulation Animals Humans Regulatory Elements Transcriptional Molecular Biology Information Systems
Zdroj:	Briefings in Bioinformatics. 8:266-274
ISSN:	1477-4054 1467-5463
DOI:	10.1093/bib/bbm027
Popis:	The recognition of transcription factor binding sites (TFBSs) is the first step on the way to deciphering the DNA regulatory code. There is a large variety of experimental approaches providing information on TFBS location in genomic sequences. Many computational approaches to TFBS recognition based on the experimental data obtained are available, each having its own advantages and shortcomings. This article provides short review of approaches to computational recognition of TFBS in genomic sequences and methods of experimental verification of predicted sites. We also present a case study of the interplay between experimental and theoretical approaches to the successful prediction of Steroidogenic Factor 1 (SF1).
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f22fa103c22434465975b415cb7aca3 https://doi.org/10.1093/bib/bbm027 Zobrazit plný text záznamu Plný text ve formátu PDF