| Autor: |
Lilian Yan Liang, Terry Cheuk‐Fung Yip, Jimmy Che‐To Lai, Amy Shuk‐Man Lam, Yee‐Kit Tse, Vicki Wing‐Ki Hui, Henry Lik‐Yuen Chan, Vincent Wai‐Sun Wong, Grace Lai‐Hung Wong |
| Rok vydání: |
2022 |
| Předmět: |
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| Zdroj: |
Journal of medical virologyREFERENCES. 94(9) |
| ISSN: |
1096-9071 |
| Popis: |
Tenofovir alafenamide (TAF) is a novel prodrug of tenofovir for the treatment of chronic hepatitis B (CHB) infection. We aimed to evaluate the impact of switching to TAF on alanine aminotransferase (ALT) normalization and renal safety. We also described the indications of switching to TAF. Consecutive adult CHB patients switched from tenofovir disoproxil fumarate (TDF) dominant therapy to TAF for more than 12 months were identified retrospectively. A subgroup of patients newly switched to TAF was prospectively invited to perform transient elastography examination and dual-energy X-ray absorptiometry. The time of switching to TAF was defined as baseline. Among 393 patients in the retrospective cohort, the median ALT at month 12 was significantly lower (21.0 [16.0-29.9] U/L vs. 25.0 [19.0-34.0] U/L; p 0.001) and ALT normalization rate was higher (89.9% vs. 83.7%; p = 0.037) than those at baseline. Estimated glomerular filtration rate decreased from 12 months before baseline and then increased from baseline to month 12 significantly (69.7 ± 22.0 ml/min/1.73 m |
| Databáze: |
OpenAIRE |
| Externí odkaz: |
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