Micelles Based on Amphiphilic PCL-PEO Triblock and Star-shaped Diblock Copolymers: Potential in Drug Delivery Applications
| Autor: | Maria Immacolata La Rotonda, M. Canciello, Giuseppe Nese, Francesca Ungaro, Rosario Palumbo, Fabiana Quaglia, Luisanna Ostacolo, Giovanni Maglio, Giuseppe De Rosa |
|---|---|
| Přispěvatelé: | Quaglia, Fabiana, Ostacolo, Luisanna, G., Nese, Canciello, Mariarosaria, DE ROSA, Giuseppe, Ungaro, Francesca, Palumbo, Rosario, LA ROTONDA, MARIA IMMACOLATA, Maglio, Giovanni |
| Jazyk: | angličtina |
| Rok vydání: | 2008 |
| Předmět: |
Materials science
Erythrocytes Polyesters Size-exclusion chromatography Biomedical Engineering Biocompatible Materials Micelle Hemolysis Biomaterials Differential scanning calorimetry Amphiphile Polymer chemistry Copolymer Humans Cells Cultured Micelles Drug Carriers Calorimetry Differential Scanning technology industry and agriculture Metals and Alloys Polymerization Drug delivery Ceramics and Composites Chromatography Gel Nanoparticles micelles • block copolymers • poly( -caprolactone) • poly(ethyleneoxide) • drug delivery Nanocarriers HeLa Cells |
| Popis: | In this work, the potential in drug nanodelivery of micelles made from poly(ϵ-caprolactone) (PCL) and poly (ethyleneoxide) (PEO) copolymers with triblock and star-diblock architectures was explored. Linear and 4-arm star-shaped PCL macromers with two or four OH end groups were prepared by ring-opening polymerization of CL and condensed with α-methoxy-ω-carboxy-PEO. The resulting amphiphilic copolymers were characterized by 1H NMR, size exclusion chromatography, and differential scanning calorimetry. Separate PCL and PEO crystalline phases were observed for both copolymers. Copolymers self-assembled in water giving critical association concentrations in the range 0.010–0.023 mg/mL. Micelles with a size of 32–45 nm were prepared by dialysis and characterized for hydrodynamic diameter and surface charge. Their potential as nanocarriers in drug delivery applications was evaluated too. Micelles were nontoxic to both Red blood cells and HeLa cells. Complement activation experiments indicated that micelles can escape the reticuloendothelial system once intravenously injected. Finally, a different uptake on HeLa cells was found for micelles obtained from triblock and star-shaped copolymers. © 2008 Wiley Periodicals, Inc. J Biomed Mater Res, 2008 |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|