Analysis of TRIM21 Genetic Variants on the Clinicopathologic Characteristics of Patients with Hepatocellular Carcinoma
| Autor: | Ying-Ru Pan, Hsiang-Ling Wang, Shun-Fa Yang, Hsiang-Lin Lee, Chao-Hsuan Chen, Yung-Luen Yu, Yi-Chung Chien, Li-Yuan Bai, Whei-Ling Chiang, Shuo-Chueh Chen, Tsai-Kun Wu, Kuan-Chun Hsueh |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
0301 basic medicine
Bioengineering Single-nucleotide polymorphism Biology lcsh:Chemical technology law.invention lcsh:Chemistry 03 medical and health sciences hepatocellular carcinoma (HCC) 0302 clinical medicine single nucleotide polymorphism (SNP) law Genetic variation medicine Chemical Engineering (miscellaneous) lcsh:TP1-1185 Allele Gene neoplasms Polymerase chain reaction Process Chemistry and Technology Genetic variants Cancer medicine.disease digestive system diseases 030104 developmental biology lcsh:QD1-999 030220 oncology & carcinogenesis Hepatocellular carcinoma Cancer research tripartite motif 21 (TRIM21) |
| Zdroj: | Processes, Vol 9, Iss 495, p 495 (2021) Processes Volume 9 Issue 3 |
| ISSN: | 2227-9717 |
| Popis: | Tripartite motif 21 (TRIM21) plays an important role in hepatocellular carcinoma (HCC). However, the gene polymorphisms of TRIM21 in HCC is not as well known. In this study, two single nucleotide polymorphisms (SNPs) in the TRIM21 gene, rs4144331, and re915956, were selected to investigate correlations between these SNPs and susceptibility to HCC. Two SNPs of the TRIM21 gene from 1196 controls without cancer and 394 HCC patients were analyzed using real-time polymerase chain reaction. These results were further analyzed to expound the associations between these TRIM21 polymorphisms and the risk of HCC as well as the impact of these SNPs on clinicopathological characteristics of HCC. After adjustment for other covariants, we observed that that younger patients (< 65 years) with the TRIM21 rs915956 A allele had a probability of HCC (AOR = 3.153, 95% CI: 1.315–7.516, p = 0.010). Moreover, patients with a smoking habit who carried the T allele of rs4144331 had more probability of HCC (AOR = 2.940, 95% CI: 1.331–6.491, p = 0.008). In addition, we observed that the polymorphic T allele of rs4144331 led to distant metastasis. Thus, our findings suggest that genetic variations in TRIM21 may correlate to HCC and evaluate distant metastasis in patients with HCC. |
| Databáze: | OpenAIRE |
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