Current and future imaging of acute cerebral ischemia: assessment of tissue viability by perfusion imaging
| Autor: | Matthew L. White, Jerome P. Quets, Paul Y. Hahn, Toshihiro Ueda, Shoichiro Otake, Toshiaki Taoka, William T.C. Yuh, Joan E. Maley |
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| Rok vydání: | 1999 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Ischemia Perfusion scanning Brain Ischemia Fibrinolytic Agents medicine Animals Humans Radiology Nuclear Medicine and imaging Thrombolytic Therapy Radiation treatment planning Tomography Emission-Computed Single-Photon medicine.diagnostic_test Vascular disease business.industry Reproducibility of Results Thrombolysis medicine.disease Cerebral blood flow Cerebrovascular Circulation Acute Disease Radiology business Perfusion Emission computed tomography Blood Flow Velocity |
| Zdroj: | ResearcherID |
| ISSN: | 0363-8715 |
| Popis: | With the advances and availability of new imaging modalities, the role of imaging of acute stroke has been broadened from making diagnosis to providing valuable information for patient management. We need to have rapid diagnostic modalities that distinguish reversible ischemic tissue from irreversibly damaged tissue for successful thrombolytic therapy. Although diffusion imaging has been reported to have both high sensitivity and specificity for acute ischemia in clinical studies, previous reports do not conclude whether the diffusion abnormality is indicative of reversibly or irreversibly injured tissue. Perfusion imaging such as perfusion magnetic resonance imaging and single-photon emission computed tomography may have the potential for providing useful information that determines tissue viability and/or reversibility. Cerebral blood flow thresholds evaluated by pretreatment single-photon emission computed tomography provide important information that is potentially useful in the management of acute stroke patients with intra-arterial thrombolysis. Perfusion imaging, when combined with diffusion imaging, may thus be potentially useful in improving patient selection for thrombolytic therapy. |
| Databáze: | OpenAIRE |
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