Post-stroke BDNF Concentration Changes Following Physical Exercise: A Systematic Review

Autor: Marcela A. Silva-Couto, Carolina Carmona Alcantara, Gabriela Lopes dos Santos, Darcy S. Reisman, Thiago Luiz Russo, Luisa Fernanda García-Salazar
Rok vydání: 2018
Předmět:
0301 basic medicine
Nerve Cell Plasticity
medicine.medical_treatment
Review
lcsh:RC346-429
0302 clinical medicine
Cerebrovascular Accident
Staircase Reaching Test
Aerobic Exercise
Constraint Induced Movement Therap
Ejercicios terapéuticos
Stroke
Rehabilitation
exercise
stroke
Constraint-induced movement therapy
Treatment Outcome
Neurology
Treadmill Exercise
Human
medicine.medical_specialty
neuroplasticity
MEDLINE
Physical exercise
CINAHL
Accidente cerebrovascular
Brain-derived neurotrophic factor
rehabilitation
03 medical and health sciences
Physical medicine and rehabilitation
Functional Task Training
medicine
Aerobic exercise
Exercise
lcsh:Neurology. Diseases of the nervous system
Movement Therapy
business.industry
Protein Secretion
Physical Activity
medicine.disease
Nonhuman
Ejercicio
Enfermedades
Protein Blood Level
030104 developmental biology
Brain Derived Neurotrophic Factor
Therapy Effect
Neurology (clinical)
Systematic Review
business
030217 neurology & neurosurgery
Zdroj: Frontiers in Neurology
Frontiers in Neurology, Vol 9 (2018)
Binder, D.K., Scharfman, H.E., Brain-derived neurotrophic factor (2004) Growth Factors, 22, pp. 123-131
Repositorio EdocUR-U. Rosario
Universidad del Rosario
instacron:Universidad del Rosario
ISSN: 1664-2295
Popis: Background: Research over the last two decades has highlighted the critical role of Brain-derived neurotrophic factor (BDNF) in brain neuroplasticity. Studies suggest that physical exercise may have a positive impact on the release of BDNF and therefore, brain plasticity. These results in animal and human studies have potential implications for the recovery from damage to the brain and for interventions that aim to facilitate neuroplasticity and, therefore, the rehabilitation process. Purpose: The aim of this study was to carry out a systematic review of the literature investigating how aerobic exercises and functional task training influence BDNF concentrations post-stroke in humans and animal models. Data Sources: Searches were conducted in PubMed (via National Library of Medicine), SCOPUS (Elsevier), CINAHL with Full Text (EBSCO), MEDLINE 1946-present with daily updates (Ovid) and Cochrane. Study Selection: All of the database searches were limited to the period from January, 2004 to May, 2017. Data Extraction: Two reviewers extracted study details and data. The methodological quality of the studies that used animal models was assessed using the ARRIVE Guidelines, and the study that evaluated human BDNF was assessed using the PEDro Scale. Data Synthesis: Twenty-one articles were included in this review. BDNF measurements were performed systemically (serum/plasma) or locally (central nervous system). Only one study evaluated human BDNF concentrations following physical exercise, while 20 studies were experimental studies using a stroke model in animals. A wide variation was observed in the training protocol between studies, although treadmill walking was the most common type of intervention among the studies. Studies were of variable quality: the studies that used animal models scored from 8/20 to 15/20 according to the ARRIVE Guidelines. The only study that evaluated human subjects scored 5/10 according to the PEDro scale and, which indicates a quality classified as "fair". Conclusions: The results of the current systematic review suggest that aerobic exercise promotes changes in central BDNF concentrations post-stroke. On the other hand, BDNF responses following functional exercises, such as reaching training and Constraint Induced Movement Therapy (CIMT), seem to be still controversial. Given the lack of studies evaluating post-stroke BDNF concentration following physical exercise in humans, these conclusions are based on animal work. © 2018 Alcantara, García-Salazar, Silva-Couto, Santos, Reisman and Russo.
Databáze: OpenAIRE
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