Postprandial responses of individual fatty acids in subjects homozygous for the threonine- or alanine-encoding allele in codon 54 of the intestinal fatty acid binding protein 2 gene
| Autor: | Matti Uusitupa, Jyrki J. Ågren, R. Valve, Markku Laakso, Helvi M. Vidgren |
|---|---|
| Rok vydání: | 2001 |
| Předmět: |
Male
Threonine Very low-density lipoprotein Time Factors Cholesterol VLDL Medicine (miscellaneous) Biology Fatty Acid-Binding Proteins Fatty acid-binding protein chemistry.chemical_compound Chylomicrons Humans Insulin Codon Alleles Aged chemistry.chemical_classification Alanine Polymorphism Genetic Nutrition and Dietetics Cholesterol Tumor Suppressor Proteins Fatty Acids Homozygote Fatty acid Middle Aged Postprandial Period Fish oil Lipids Neoplasm Proteins Intestines Postprandial chemistry Biochemistry Female lipids (amino acids peptides and proteins) Carrier Proteins Fatty Acid-Binding Protein 7 Polyunsaturated fatty acid Chylomicron |
| Zdroj: | The American Journal of Clinical Nutrition. 73:31-35 |
| ISSN: | 0002-9165 |
| DOI: | 10.1093/ajcn/73.1.31 |
| Popis: | Background The affinity of intestinal fatty acid binding protein (FABP) for fatty acids is regulated by the polymorphism at codon 54 of the FABP2 gene (alanine-to-threonine shift). We found earlier that the threonine-encoding allele (Thr54) is associated with an increased postprandial lipemic response. Objective We studied the postprandial responses of individual fatty acids in subjects homozygous for the Thr54 or alanine-encoding allele (Ala54). Design Oral-fat-loading tests were performed in 8 subjects homozygous for Thr54 and in 7 subjects homozygous for Ala54. Results The postprandial responses of most of the 14-18-carbon fatty acids in chylomicron and VLDL triacylglycerols were significantly elevated in the Thr54 homozygotes whereas the relative increases in these fatty acids were not significantly different in both groups. The amounts of 20- and 22-carbon polyunsaturated fatty acids started to increase later than the amounts of shorter ones after the test meal, and the differences between the groups were mostly insignificant. The responses of chylomicron fatty acids correlated positively with postprandial insulin response in the Thr54 homozygotes and inversely in the Ala54 homozygotes. VLDL fatty acid responses correlated with fasting triacylglycerol concentrations in the Ala54 homozygotes but not in the Thr54 homozygotes. Conclusion The threonine-encoding allele of the FABP2 gene is associated with an increased postprandial response of 14-18-carbon fatty acids but not with changes in the relative amounts of individual fatty acids introduced to chylomicron triacylglycerols. |
| Databáze: | OpenAIRE |
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