Construction of an m6A‐related lncRNA pair prognostic signature and prediction of the immune landscape in head and neck squamous cell carcinoma
| Autor: | Qun Li, Zhisen Shen, Dong Ye, Yiming Shen, Yi Shen, Jinyun Li, Chongchang Zhou, Hongxia Deng, Juntao Huang, Guowen Zhan, Shumin Wang |
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| Jazyk: | angličtina |
| Rok vydání: | 2021 |
| Předmět: |
Microbiology (medical)
Oncology medicine.medical_specialty Adenosine medicine.medical_treatment Clinical Biochemistry N6‐methylandenosine medicine.disease_cause head and neck squamous cell carcinoma Transcriptome Germline mutation Internal medicine medicine Biomarkers Tumor Immunology and Allergy Humans Research Articles Mutation Proportional hazards model business.industry Squamous Cell Carcinoma of Head and Neck Biochemistry (medical) Public Health Environmental and Occupational Health Hematology Immunotherapy medicine.disease Prognosis Head and neck squamous-cell carcinoma Long non-coding RNA Log-rank test Medical Laboratory Technology Head and Neck Neoplasms long non‐coding RNA RNA Long Noncoding business Research Article |
| Zdroj: | Journal of Clinical Laboratory Analysis |
| ISSN: | 1098-2825 0887-8013 |
| Popis: | Background Mounting evidence indicates that aberrantly expressed N6‐methylandenosine (m6A) modification regulators and long noncoding RNA (lncRNA) influence the development of head and neck squamous cell carcinoma (HNSCC). However, the prognosis of m6A‐related lncRNA (mrlncRNA) in HNSCC has not yet been evaluated. Methods We retrieved transcriptome, somatic mutation, and clinical information from The Cancer Genome Atlas database and established a differently expressed mrlncRNA (DEmrlncRNA) pair signature based on least absolute shrinkage and selection operator Cox regression and multivariate Cox analyses. Each sample's risk score was computed premised on the signature, which accurately classified patients into low‐ and high‐risk group by the cut‐off point. The signature was evaluated from the perspective of survival, clinicopathological characteristics, tumor mutation burden (TMB), immune cell infiltration, efficacy of chemotherapeutics, tumor immune microenvironment, and immune checkpoint inhibitor (ICI)‐related genes. Results 11 DEmrlncRNA pairs were identified and were used to construct the prediction signature. Kaplan–Meier plotter revealed a worse prognosis in high‐risk patients over low‐risk patients (log rank p The m6A‐related lncRNA pair prognostic signature was evaluated from the perspective of survival, clinicopathological features, immune cell infiltration, tumor immune microenvironment, tumor mutation burden, efficacy of chemotherapeutics, and immune checkpoint inhibitor ‐related genes. The m6A‐related lncRNA pair signature was an efficient independent prognostic indicator and may provide a rationale for research on immunotherapeutic and chemotherapeutics strategies for HNSCC patients. |
| Databáze: | OpenAIRE |
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