Impaired planning in patients with obsessive-compulsive disorder and unaffected first-degree relatives: Evidence for a cognitive endophenotype
| Autor: | Rosa Grützmann, Michael Wagner, Anja Riesel, Julia Klawohn, Leonhard Lennertz, Norbert Kathmann, Stephan Heinzel, Christian Kaufmann, Katharina Bey |
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| Rok vydání: | 2018 |
| Předmět: |
Adult
Male Obsessive-Compulsive Disorder complications [Cognition Disorders] Endophenotypes psychology [Cognition Disorders] Affect (psychology) behavioral disciplines and activities complications [Obsessive-Compulsive Disorder] Executive Function 03 medical and health sciences Cognition 0302 clinical medicine ddc:150 Obsessive compulsive mental disorders medicine Humans In patient First-degree relatives Problem Solving Family Health psychology [Obsessive-Compulsive Disorder] Small sample Middle Aged medicine.disease Comorbidity 030227 psychiatry Psychiatry and Mental health Clinical Psychology Endophenotype Female Cognition Disorders Psychology 030217 neurology & neurosurgery Clinical psychology |
| Zdroj: | Journal of anxiety disorders 57, 24-30 (2018). doi:10.1016/j.janxdis.2018.05.009 |
| ISSN: | 0887-6185 |
| DOI: | 10.1016/j.janxdis.2018.05.009 |
| Popis: | Patients with obsessive-compulsive disorder (OCD) show deficient planning capacity in the Tower of London (TOL) problem solving task. Preliminary evidence for similar deficits in unaffected first-degree relatives suggests that impaired planning may constitute an endophenotype of OCD. However, results on this issue are inconsistent, possibly owing to small sample sizes and variability in problem structure across TOL tasks. Here, we adopted a computerized version of the TOL task featuring a 2 × 2 factorial design (high/low search depth × full/partial tower goal state) and examined a well-characterized sample of n = 72 OCD patients, n = 76 unaffected first-degree relatives and n = 102 healthy comparison subjects. Both OCD patients and relatives exhibited significantly less accurate problem solving than controls. Search depth, goal hierarchy, or the number of minimum moves did not moderate these group differences. Medication, OCD symptoms, and depressive comorbidity did not affect TOL performance in patients, suggesting a state-independent effect. In conclusion, we found that OCD patients as well as unaffected first-degree relatives show deficient TOL performance across a range of task conditions, strongly supporting the role of impaired planning as an endophenotype of OCD, and contributing to the growing evidence for fronto-striatal dysfunctions in OCD. |
| Databáze: | OpenAIRE |
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