The relationship of acute insulin sensitivity to the progression of vascular disease in long-term Type 1 (insulin-dependent) diabetes mellitus
Autor: | F. I. R. Martin, J. L. Hopper |
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Rok vydání: | 1987 |
Předmět: |
Blood Glucose
medicine.medical_specialty Time Factors Endocrinology Diabetes and Metabolism medicine.medical_treatment Diabetes mellitus Internal medicine Intravenous insulin Internal Medicine medicine Humans Insulin Glycated Hemoglobin Chemotherapy Vascular disease business.industry Insulin sensitivity Middle Aged Prognosis medicine.disease Diabetes Mellitus Type 1 Endocrinology Insulin dependent diabetes Complication business Diabetic Angiopathies Follow-Up Studies |
Zdroj: | Diabetologia. 30:149-153 |
ISSN: | 1432-0428 0012-186X |
DOI: | 10.1007/bf00274219 |
Popis: | In 51 individuals with Type 1 (insulin-dependent) diabetes mellitus initially of more than 15 years' duration, the acute hypoglycaemic effect of intravenous insulin (0.11 IU/kg) was related to outcome over 18 years. This acute insulin sensitivity, or glucose assimilation index, was reproducible over the period of study. At 18-year follow-up, initial low glucose assimilation index (less than 0.082 mmol X l-1 X min-1 was significantly (p less than 0.01) associated with death from vascular disease. Low glucose assimilation index was similarly significantly (p less than 0.01) associated with progression of atherosclerotic disease, but not with microangiopathy alone. Hypertension (systolic blood pressure greater than 150 mmHg and/or diastolic blood pressure greater than 95 mmHg) was the only other parameter significantly (p less than 0.01) related to outcome, but this relationship was no longer significant once glucose assimilation index had been taken into account. A linear logistic analysis confirmed that acute insulin sensitivity was independently associated with outcome. Neither initial clinical control of diabetes nor glycosylated haemoglobin level in the 26 survivors was related to vascular prognosis. |
Databáze: | OpenAIRE |
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