Pulmonary artery haemorrhage in newborn calves following bluetongue virus serotype 8 experimental infections of pregnant heifers
| Autor: | Kris De Clercq, Christine Thys, Ludovic Martinelle, Etienne Thiry, Claude Saegerman, Ilse De Leeuw, Fabiana Dal Pozzo, Pierre Sarradin |
|---|---|
| Přispěvatelé: | Faculty of Veterinary Medicine, Plateforme d'Infectiologie Expérimentale (PFIE), Institut National de la Recherche Agronomique (INRA), Sciensano [Bruxelles], Réseau International des Instituts Pasteur (RIIP) |
| Rok vydání: | 2013 |
| Předmět: |
[SDV.OT]Life Sciences [q-bio]/Other [q-bio.OT]
040301 veterinary sciences Offspring Placenta Cattle Diseases Context (language use) Biology Pulmonary Artery Antibodies Viral Microbiology Bluetongue 0403 veterinary science 03 medical and health sciences Bluetongue disease Pregnancy medicine.artery medicine Animals Experimental infection Transplacental Pregnancy Complications Infectious 030304 developmental biology 2. Zero hunger 0303 health sciences Sheep General Veterinary Vaccination Outbreak Brain 04 agricultural and veterinary sciences General Medicine medicine.disease Virology Antibodies Neutralizing Europe [SDV.MP]Life Sciences [q-bio]/Microbiology and Parasitology Milk Haemorrhage In utero Pulmonary artery biology.protein Gestation RNA Viral Cattle Female Antibody Bluetongue virus |
| Zdroj: | Veterinary Microbiology Veterinary Microbiology, Elsevier, 2013, 167 (3-4), pp.250-259. ⟨10.1016/j.vetmic.2013.08.016⟩ |
| ISSN: | 1873-2542 0378-1135 |
| DOI: | 10.1016/j.vetmic.2013.08.016⟩ |
| Popis: | International audience; The emergence of bluetongue disease (BT) among livestock in Europe in 2006 raised many questions including the occurrence and epidemiological significance of foetal infections in cattle. To clarify these aspects, vaccinated and unvaccinated pregnant heifers were sequentially infected twice in an isolation facility (biosafety level 3) with a northern European outbreak strain of Bluetongue virus serotype 8 (BTV-8). The study was terminated 2 months after calving with necropsy of the dams and their offspring. The cattle were monitored throughout the study by clinical scoring and for the presence of circulating neutralising antibodies, and after calving for the presence of infectious virus and viral RNA in blood and milk. Four calves, one born from a vaccinated dam and three from non-vaccinated ones, that were infected at 120 days of gestation had obvious haemorrhage of the pulmonary artery at necropsy. Although haemorrhage of the pulmonary artery is highly characteristic of BT, viral RNA was not detected in any of these calves. Furthermore, although none of the calves born from heifers infected prior to mid-gestation had teratogenic BTV typical brain lesions, some had lesions at birth suggestive of in utero BTV infection. Despite the lack of viral RNA detection, the presence of haemorrhage of the pulmonary artery deserves to be reported as a new observation in the context of the multiple investigations having as main subject the BTV placental crossing in cattle. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|
Full Text from ScienceDirect