Investigation of Chlamydia pneumoniae Infection in Patients With Multiple Sclerosis: A Case-Control Study
| Autor: | Mohammad Taheri, Ali Reza Soltanian, Mehrdokht Mazdeh, Sima Kazemi, Mohammad Yousef Alikhani, Bahareh Lashtoo Aghaee |
|---|---|
| Jazyk: | angličtina |
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty 030106 microbiology multiple sclerosis Immunoglobulin G lcsh:Infectious and parasitic diseases Pathogenesis 03 medical and health sciences 0302 clinical medicine Internal medicine medicine lcsh:RC109-216 030212 general & internal medicine Chlamydia biology business.industry Multiple sclerosis Incidence (epidemiology) Case-control study General Medicine medicine.disease chlamydia pneumoniae Pneumonia Etiology biology.protein elisa business |
| Zdroj: | Avicenna Journal of Clinical Microbiology and Infection, Vol 7, Iss 2, Pp 36-39 (2020) |
| ISSN: | 2383-0301 2383-0298 |
| Popis: | Background: Chlamydia pneumonia has currently been proposed to be involved in multiple sclerosis (MS) pathogenesis. The aim of this study was to evaluate the serum level of anti-C. pneumoniae immunoglobulin G (IgG) in patients with MS compared to the control group, which may be helpful in further understanding of MS etiology. Methods: The serum was obtained from 66 people with MS and 20 healthy people as patient and control groups, respectively. Serums were matched to the patient’s age, gender, and place of residence. Finally, anti-C. pneumoniae IgG was measured by a sandwich enzyme-linked immunosorbent assay (ELISA). Results: Sixty-six patients (25 men and 41 women within the age range of 17-56 years and mean±SD of 35.53±9.56) with MS and 20 control subjects (8 men and 12 women with the age range of 25-56 and mean±SD of 38.3±9.66) were enrolled in this study. The mean serum anti-C. pneumoniae IgG of patients with MS (28.82±33.54 RU/mL) was compared with that of the control group (4.075±6.691 RU/mL) and a statistically significant difference was observed in this regard (P |
| Databáze: | OpenAIRE |
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