Pharmacokinetics and selected pharmacodynamics of romifidine following low-dose intravenous administration in combination with exercise to quarter horses
| Autor: | D. S. Mckemie, Heather K Knych, Scott D Stanley, S. J. Steinmetz |
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| Rok vydání: | 2016 |
| Předmět: |
040301 veterinary sciences
Sedation Pharmacology 0403 veterinary science 03 medical and health sciences 0302 clinical medicine Blood serum Pharmacokinetics 030202 anesthesiology Heart Rate Physical Conditioning Animal Heart rate medicine Adrenergic alpha-2 Receptor Agonists Animals Horses Romifidine Volume of distribution General Veterinary Dose-Response Relationship Drug business.industry Imidazoles Half-life 04 agricultural and veterinary sciences Anesthesia Pharmacodynamics Injections Intravenous Administration Intravenous medicine.symptom business medicine.drug |
| Zdroj: | Journal of veterinary pharmacology and therapeutics. 40(5) |
| ISSN: | 1365-2885 |
| Popis: | Romifidine is an alpha-2 adrenergic agonist used for sedation and analgesia in horses. As it is a prohibited substance, its purported use at low doses in performance horses necessitates further study. The primary goal of the study reported here was to describe the serum concentrations and pharmacokinetics of romifidine following low-dose administration immediately prior to exercise, utilizing a highly sensitive liquid chromatography-tandem mass spectrometry assay that is currently employed in many drug testing laboratories. An additional objective was to describe changes in heart rate and rhythm following intravenous administration of romifidine followed by exercise. Eight adult Quarter Horses received a single intravenous dose of 5 mg (0.01 mg/kg) romifidine followed by 1 h of exercise. Blood samples were collected and drug concentrations measured at time 0 and at various times up to 72 h. Mean ± SD systemic clearance, steady-state volume of distribution and terminal elimination half-life were 34.1 ± 6.06 mL/min/kg and 4.89 ± 1.31 L/kg and 3.09 ± 1.18 h, respectively. Romifidine serum concentrations fell below the LOQ (0.01 ng/mL) and the LOD (0.005 ng/mL) by 24 h postadministration. Heart rate and rhythm appeared unaffected when a low dose of romifidine was administered immediately prior to exercise. |
| Databáze: | OpenAIRE |
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