Biosensors for early diagnosis of pancreatic cancer: a review
| Autor: | Wei Chen, Qiaobin Li, Lisheng Qian, Kwaku Baryeh, Randall E. Brand, Jing Zhang, Xueji Zhang, Wanwei Qiu, Li Kun, Guodong Liu, Qingcai Yu, Dongqin Xu, Liu Wenju |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
Poor prognosis medicine.medical_specialty Optics and Photonics Disease Biosensing Techniques 03 medical and health sciences 0302 clinical medicine Physiology (medical) Pancreatic cancer Biopsy medicine Biomarkers Tumor Relative survival rate Humans Stage (cooking) Intensive care medicine Early Detection of Cancer medicine.diagnostic_test business.industry Biochemistry (medical) High mortality Public Health Environmental and Occupational Health Cancer General Medicine Electrochemical Techniques medicine.disease Pancreatic Neoplasms 030104 developmental biology 030220 oncology & carcinogenesis business |
| Zdroj: | Translational research : the journal of laboratory and clinical medicine. 213 |
| ISSN: | 1878-1810 |
| Popis: | Pancreatic cancer is characterized by extremely high mortality and poor prognosis and is projected to be the leading cause of cancer deaths by 2030. Due to the lack of early symptoms and appropriate methods to detect pancreatic carcinoma at an early stage as well as its aggressive progression, the disease is often quite advanced by the time a definite diagnosis is established. The 5-year relative survival rate for all stages is approximately 8%. Therefore, detection of pancreatic cancer at an early surgically resectable stage is the key to decrease mortality and to improve survival. The traditional methods for diagnosing pancreatic cancer involve an imaging test, such as ultrasound or magnetic resonance imaging, paired with a biopsy of the mass in question. These methods are often expensive, time consuming, and require trained professionals to use the instruments and analyze the imaging. To overcome these issues, biosensors have been proposed as a promising tool for the early diagnosis of pancreatic cancer. The present review critically discusses the latest developments in biosensors for the early diagnosis of pancreatic cancer. Protein and microRNA biomarkers of pancreatic cancer and corresponding biosensors for pancreatic cancer diagnosis have been reviewed, and all these cases demonstrate that the emerging biosensors are becoming an increasingly relevant alternative to traditional techniques. In addition, we discuss the existing problems in biosensors and future challenges. |
| Databáze: | OpenAIRE |
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