STEREOSELECTIVE FORMATION OF 4-SUBSTITUTED-1,4-DIHYDRONICOTINOYL COMPLEXES UTILIZING THE CHIRAL AUXILIARY [(ETA-5-C5H5)FE(CO)(PPH3)]

Autor:	Stephen G. Davies, Paul Beckett, Mark Whittaker, Vicky A. Burgess
Rok vydání:	2016
Předmět:	chemistry.chemical_compound Chiral auxiliary Proton Nucleophile Chemistry Organic Chemistry Drug Discovery Diastereomer Organic chemistry Stereoselectivity Chloroformate Biochemistry Medicinal chemistry
DOI:	10.1016/s0040-4039(00)73651-3
Popis:	Completely regio- and stereoselective additions of nucleophiles to ( RS )-[(η 5 -C 5 H 5 )Fe(CO)(PPh 3 )nicotinoyl] 1 occur at C-4 to give the corresponding nitrogen-stabilized anions which may be quenched by a proton, a chloroformate or dimethylsulphate to give the corresponding 1,4-dihydronicotinoyl complexes as single diastereoisomers.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f099c884fcbf2dacd87e71358156978 https://doi.org/10.1016/s0040-4039(00)73651-3 Zobrazit plný text záznamu