Cumulative Evidence for Association of IL-10 -1082G > A Polymorphism with Susceptibility to Recurrent Pregnancy Loss: A Systematic Review and Meta-Analysis
| Autor: | Razieh Sadat Tabatabaei, Atiyeh Javaheri, Leila Zanbagh, Hossein Neamatzadeh, Athena Behforouz, Sara Soleimani-Jadidi, Bahare Meibodi, Amaneh Hadadan, Hajar Abbasi |
|---|---|
| Rok vydání: | 2020 |
| Předmět: |
0301 basic medicine
Oncology Abortion Habitual medicine.medical_specialty Subgroup analysis 030105 genetics & heredity Pathology and Forensic Medicine 03 medical and health sciences Global population 0302 clinical medicine Pregnancy Risk Factors Internal medicine Recurrent miscarriage medicine Humans Pooled data Polymorphism Genetic 030219 obstetrics & reproductive medicine business.industry General Medicine medicine.disease Interleukin-10 Interleukin 10 Case-Control Studies Meta-analysis Pediatrics Perinatology and Child Health Female business Systematic search |
| Zdroj: | Fetal and Pediatric Pathology. 40:471-485 |
| ISSN: | 1551-3823 1551-3815 |
| DOI: | 10.1080/15513815.2020.1716903 |
| Popis: | BACKGROUND The IL-10 -1082 G > A polymorphism has been reported to be associated with a risk of recurrent pregnancy loss (RPL) with inconsistent results. Thus, to clarify the effect of the polymorphism on the susceptibility to RPL, a meta-analysis was performed. Methods: A systematic literature search in PubMed, Web of Science, Scopus and SciELO was performed to identify the relevant studies published up to December 20, 2019, and related information was extracted. Results: A total of 17 case-control studies with 3,224 RPL cases and 3,295 controls were selected. Pooled data revealed that IL-10 -1082 G > A polymorphism was significantly associated with risk of RPL in the global population. Moreover, subgroup analysis indicated a significant association in Caucasians, but not in Asian or mixed populations. Conclusions: Our pooled data highlights that IL-10 -1082 G > A polymorphism is a risk factor for RPL susceptibility in the global population, especially in Caucasians. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|