A new indanone from the marine cyanobacterium Lyngbya majuscula that inhibits hypoxia-induced activation of the VEGF promoter in Hep3B cells

Autor:	Peter U. Park, David S. Pasco, Dale G. Nagle, Yu-Dong Zhou, Christine J. G. Duncan, Valerie J. Paul, Ira Rajbhandari
Rok vydání:	2000
Předmět:	Vascular Endothelial Growth Factor A Angiogenesis Pharmaceutical Science Endothelial Growth Factors Cyanobacteria Analytical Chemistry chemistry.chemical_compound Drug Discovery medicine Tumor Cells Cultured Humans Promoter Regions Genetic Lyngbya majuscula Pharmacology Lymphokines biology Vascular Endothelial Growth Factors Organic Chemistry Promoter biology.organism_classification Molecular biology In vitro Cell Hypoxia Vascular endothelial growth factor Vascular endothelial growth factor A medicine.anatomical_structure Complementary and alternative medicine chemistry Biochemistry Gene Expression Regulation Cell culture Hepatocyte Indans Molecular Medicine
Zdroj:	Journal of natural products. 63(10)
ISSN:	0163-3864
Popis:	A new indanone (1) has been isolated from the filamentous marine cyanobacterium Lyngbya majuscula, and its structure determined spectroscopically. Vascular endothelial growth factor (VEGF) is an important regulator of tumor angiogenesis. Compound 1 inhibits hypoxia-induced activation of the VEGF gene promoter in Hep3B human liver tumor cells, in vitro.
Databáze:	OpenAIRE
Externí odkaz:	https://explore.openaire.eu/search/publication?articleId=doi_dedup___::4f053976caf8ce9a05c2e4e49164d45f https://pubmed.ncbi.nlm.nih.gov/11076571 Zobrazit plný text záznamu