Antiparkinsonian drug doses and neuroleptic receptors
| Autor: | Philip Seeman, M. Titeler |
|---|---|
| Rok vydání: | 1978 |
| Předmět: |
Apomorphine
In Vitro Techniques Pharmacology Tritium Receptors Dopamine Antiparkinson Agents Cellular and Molecular Neuroscience medicine Animals Potency Molecular Biology Bromocriptine Chemistry Antiparkinsonian drug Cell Biology Spiperone Dopamine receptor Direct binding Haloperidol Molecular Medicine Cattle Caudate Nucleus Neuroleptic receptors medicine.drug |
| Zdroj: | Experientia. 34:1490-1492 |
| ISSN: | 1420-9071 0014-4754 |
| DOI: | 10.1007/bf01932371 |
| Popis: | The clinical potency of 3 drugs, apomorphine, N-propylnorapomorphine, and bromocryptine, have been found to be closely correlated to their potencies in competing for 3H-haloperidol and 3H-spiroperidol both of which label the dopamine receptor. This correlation indicates that the direct binding assay may be used to predict clinical potencies of anti-parkinsonian drugs, and indicates that agonists as well as antagonists compete potently for 3H-neuroleptic binding. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
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