Metabolomics and Communication Skills Development in Children; Evidence from the Ages and Stages Questionnaire
| Autor: | Aishwarya P. Yadama, Nancy Laranjo, Kathleen Lee-Sarwar, Adrianna Boulin, Vincent J. Carey, Jessica Lasky-Su, Rachel S. Kelly, Augusto A. Litonjua, Scott T. Weiss, Su H. Chu |
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| Rok vydání: | 2019 |
| Předmět: |
0301 basic medicine
medicine.medical_specialty Endocrinology Diabetes and Metabolism Population lcsh:QR1-502 autism childhood development Biochemistry Article lcsh:Microbiology ages and stages questionnaire (ASQ) 03 medical and health sciences 0302 clinical medicine Metabolomics Internal medicine medicine education tryptophan metabolism Molecular Biology Tyrosine Metabolism education.field_of_study Childhood development N-formylanthranilic acid business.industry endocannabinoid Tryptophan Metabolism medicine.disease metabolomics serotonin tyrosine metabolism 030104 developmental biology Metabolomic profiling Autism Communication skills business 030217 neurology & neurosurgery |
| Zdroj: | Metabolites, Vol 9, Iss 3, p 42 (2019) Metabolites |
| ISSN: | 2218-1989 |
| Popis: | We hypothesized metabolomic profiling could be utilized to identify children who scored poorly on the communication component of the Ages and Stages Questionnaire (ASQ); which assesses development in childhood, and to provide candidate biomarkers for autism spectrum disorders (ASD). In a population of three-year-old children, 15 plasma metabolites, were significantly (p < 0.05) different between children who were categorized as having communication skills that were “on schedule” (n = 365 (90.6%)) as compared to those “requiring further monitoring/evaluation” (n = 38 (9.4%)) according to multivariable regression models. Five of these metabolites, including three endocannabinoids, were also dysregulated at age one (n = 204 “on schedule”, n = 24 “further monitoring/evaluation”) in the same children. Stool metabolomic profiling identified 11 significant metabolites. Both the plasma and stool results implicated a role for tryptophan and tyrosine metabolism; in particular, higher levels of N-formylanthranilic acid were associated with an improved communication score in both biosample types. A model based on the significant plasma metabolites demonstrated high sensitivity (88.9%) and specificity (84.5%) for the prediction of autism by age 8. These results provide evidence that ASQ communication score and metabolomic profiling of plasma and/or stool may provide alternative approaches for early diagnosis of ASD, as well as insights into the pathobiology of these conditions. |
| Databáze: | OpenAIRE |
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