Extensive multiplex PCR diagnostics reveal new insights into the epidemiology of viral respiratory infections
| Autor: | B. Von Wissmann, Sema Nickbakhsh, Fiona Thorburn, Jim McMenamin, Pablo R. Murcia, R. N. Gunson |
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| Rok vydání: | 2016 |
| Předmět: |
0301 basic medicine
Male pandemic influenza Epidemiology viruses risk factor analysis 0302 clinical medicine Pandemic Prevalence 030212 general & internal medicine Young adult Child Respiratory Tract Infections Aged 80 and over education.field_of_study RSV/other respiratory infections Respiratory tract infections Coinfection Middle Aged Original Papers 3. Good health Infectious Diseases Virus Diseases Child Preschool surveillance Female Seasons Adult medicine.medical_specialty Adolescent 030106 microbiology Population Biology Virus 03 medical and health sciences Young Adult Multiplex polymerase chain reaction medicine Humans education Aged Co-infections Infant Newborn Infant medicine.disease Virology Scotland Immunology Multiplex Polymerase Chain Reaction |
| Zdroj: | Epidemiology and Infection |
| ISSN: | 1469-4409 0950-2688 |
| Popis: | SUMMARYViral respiratory infections continue to pose a major global healthcare burden. At the community level, the co-circulation of respiratory viruses is common and yet studies generally focus on single aetiologies. We conducted the first comprehensive epidemiological analysis to encompass all major respiratory viruses in a single population. Using extensive multiplex PCR diagnostic data generated by the largest NHS board in Scotland, we analysed 44230 patient episodes of respiratory illness that were simultaneously tested for 11 virus groups between 2005 and 2013, spanning the 2009 influenza A pandemic. We measured viral infection prevalence, described co-infections, and identified factors independently associated with viral infection using multivariable logistic regression. Our study provides baseline measures and reveals new insights that will direct future research into the epidemiological consequences of virus co-circulation. In particular, our study shows that (i) human coronavirus infections are more common during influenza seasons and in co-infections than previously recognized, (ii) factors associated with co-infection differ from those associated with viral infection overall, (iii) virus prevalence has increased over time especially in infants aged |
| Databáze: | OpenAIRE |
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