ADDITIONAL EVIDENCE FOR CHROMOSOME ABNORMALITIES IN THE ERYTHROID PRECURSORS IN ACUTE LEUKAEMIA
| Autor: | Mogens Krogh Jensen, Sven-Aage Killmann |
|---|---|
| Rok vydání: | 2009 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Mitosis Bone Marrow Cells Chromosome Disorders Bone Marrow Erythroblast hemic and lymphatic diseases Internal Medicine medicine Humans Erythropoiesis Aged Chromosome Aberrations medicine.diagnostic_test business.industry Chromosome Bone Marrow Examination Karyotype Middle Aged Bone marrow examination Leukemia Myeloid Acute Haematopoiesis medicine.anatomical_structure Leukemia Myeloid Karyotyping Female Leukemia Erythroblastic Acute Bone marrow business |
| Zdroj: | Acta Medica Scandinavica. 189:97-100 |
| ISSN: | 0001-6101 |
| DOI: | 10.1111/j.0954-6820.1971.tb04345.x |
| Popis: | In continuation of a previous study, five additional patients with acute leukaemia have been studied, characterized by abnormal bone marrow karyotypes and fairly well represented erythropoiesis. In all five patients the percentage of erythroblast mitoses (16–62% of the bone marrow mitoses) was definitely higher than that of normal metaphases. These data confirm the previous results and suggest that, in acute myeloid leukaemia, the chromosome abnormalities are not confined to the cells of the blastic variety, but are also present in the erythroid precursors. Thus acute myeloid leukaemia is probably not a disease of the granulocytic cell line, but rather a disorder of haemopoiesis in general. |
| Databáze: | OpenAIRE |
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