Duration of antimicrobial prophylaxis in vascular surgery
| Autor: | Francis J. Prendergast, M. A. Goodman, Peta Rosenberg, John C. Hall, Michael Lawrence-Brown, Jane L. Hall, Keryn J. Christiansen, Briony Mills |
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| Rok vydání: | 1998 |
| Předmět: |
Male
medicine.medical_specialty law.invention Clavulanic Acids Pharmacotherapy Randomized controlled trial law Humans Surgical Wound Infection Ticarcillin Medicine Antibiotic prophylaxis Infusions Intravenous Aged business.industry Surgical wound General Medicine Antibiotic Prophylaxis Middle Aged Vascular surgery Surgery Regimen Treatment Outcome Anesthesia Chemoprophylaxis Drug Therapy Combination Female business Vascular Surgical Procedures medicine.drug |
| Zdroj: | The American Journal of Surgery. 175:87-90 |
| ISSN: | 0002-9610 |
| DOI: | 10.1016/s0002-9610(97)00270-5 |
| Popis: | background This randomized clinical trial compares the incidence of wound infection after vascular surgery in patients who received prophylaxis using the same antibiotic as either a single dose or a multiple-dose regimen (until the lines/ drain tubes were removed, but not for more than 5 days). methods Each of the 302 patients who entered the study received ticarcillin 3.0 g/clavulanate 0.1 g (Timentin) intravenously immediately after the induction of anesthesia. Patients randomized to the multiple-dose group received an average of 14.3 doses (range 9 to 20). results The incidence of wound infections was 18% (28 of 153) for patients in the single-dose group and 10% (15 of 149) for patients in the multiple-dose group (P = 0.04; relative risk estimate = 2.00, 95% confidence interval = −1.02 to 3.92). conclusions A multiple-dose antibiotic regimen, rather than single-dose therapy, provides optimal prophylaxis against wound infection for patients undergoing vascular surgery. |
| Databáze: | OpenAIRE |
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