Therapeutic efficacy of chloroquine for the treatment of Plasmodium vivax malaria among outpatients at Shawa Robit Health Care Centre, North-East Ethiopia
| Autor: | Sultan Suleman, Abdissa Biruksew, Seble Seifu, Ahmed Zeynudin, Endalew Zemene |
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| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Adolescent Veterinary (miscellaneous) 030106 microbiology 030231 tropical medicine Plasmodium vivax Physical examination Parasitemia Antimalarials 03 medical and health sciences 0302 clinical medicine Recurrence Chloroquine Internal medicine Outpatients parasitic diseases Malaria Vivax medicine Humans Cumulative incidence Survival analysis Aged biology Health care centre medicine.diagnostic_test business.industry Infant Middle Aged biology.organism_classification medicine.disease Survival Analysis Surgery Infectious Diseases Hematocrit Insect Science Female Parasitology Ethiopia Plasmodium vivax Malaria business Malaria medicine.drug |
| Zdroj: | Acta Tropica. 171:44-51 |
| ISSN: | 0001-706X |
| DOI: | 10.1016/j.actatropica.2017.02.027 |
| Popis: | Nearly 40% of all malaria infection in Ethiopia is caused by Plasmodium vivax. Chloroquine (CQ) is the first line treatment for confirmed P. vivax malaria in the country. However, the efficacy of this drug has been compromised by CQ resistant P. vivax (CRPv) strains. Therefore, the present study was aimed at assessing the therapeutic efficacy of CQ for treatment of P. vivax malaria at Shawa Robit Health Care Centre, North-Ease Ethiopia. A one-arm, 28-day follow-up, in vivo therapeutic efficacy study was conducted from October 2013 to February 2014. Eighty-seven patients with microscopically confirmed P. vivax mono - infection aged between 1 and 65 years were enrolled and treated with a 25mg/kg CQ administered for three consecutive days under supervision. Socio-demographic and clinical information were collected. Blood smears were prepared and examined for parasite clearance or recurrence of parasitaemia. Clinical examination was performed at all follow-up visits. Haematocrit determination was made. Percentages, frequencies, Kaplan-Meier survival probability analysis and statistical associations were computed. P-value of |
| Databáze: | OpenAIRE |
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