Use of the caprinised strain of rinderpest virus for potency testing an attenuated cell culture rinderpest vaccine
Autor: | P. Jouvenet, M. Mosienyane, M. Mannathoko, F. Guillemin |
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Rok vydání: | 1988 |
Předmět: |
Clinical Trials as Topic
Rinderpest Sheep Time Factors Fever Inoculation Goats Viral Vaccines Biology Rinderpest virus Pathogenicity biology.organism_classification Vaccines Attenuated Virology Bovine kidney Food Animals Species Specificity Cell culture Potency Animals Animal Science and Zoology Cattle |
Zdroj: | Tropical animal health and production. 20(2) |
ISSN: | 0049-4747 |
Popis: | The caprinised strain of rinderpest virus was inoculated into goats to produce a challenge stock. These goats were kept with control animals (goats, sheep, calves). In this trial the caprinised strain was shown to have a mild pathogenicity for goats and it spread to one of two contact goats but not from goats to other species. The caprinised strain was then tested on cattle where a febrile reaction was observed. The caprinised strain also did not spread between cattle. The cattle vaccinated with a freeze-dried vaccine produced from the attenuated Kabete RBKO strain on bovine kidney cells were then challenged with the caprinised strain with good results. |
Databáze: | OpenAIRE |
Externí odkaz: |
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