Gut mucosal cell damage in meningococcal sepsis in children
| Autor: | Gijs D. Vos, Else M. Bijker, Wim A. Buurman, Erik Heineman, Joep P. M. Derikx, Dick A. van Waardenburg, Annemarie A. van Bijnen |
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| Přispěvatelé: | Groningen Institute for Organ Transplantation (GIOT), Lifestyle Medicine (LM), RS: NUTRIM - R2 - Gut-liver homeostasis, Algemene Heelkunde, Kindergeneeskunde, Surgery |
| Jazyk: | angličtina |
| Rok vydání: | 2010 |
| Předmět: |
Male
Pathology Resuscitation intestinal fatty acid binding protein clinical outcome Bacteremia Critical Care and Intensive Care Medicine Gastroenterology DISEASE Cohort Studies Hospitals University Intestinal mucosa BACTERIAL TRANSLOCATION Hospital Mortality Intestinal Mucosa Child plasma marker Pediatric intensive care unit monitoring of treatment Age Factors MULTIPLE ORGAN DYSFUNCTION BARRIER DYSFUNCTION Prognosis ACID-BINDING-PROTEIN medicine.anatomical_structure Child Preschool Female medicine.medical_specialty Adolescent Enterocyte Critical Illness Meningococcal disease Fatty Acid-Binding Proteins Intensive Care Units Pediatric INTESTINAL ISCHEMIA Sepsis Sex Factors Predictive Value of Tests Internal medicine Intensive care SCORE medicine INJURY Humans Probability Retrospective Studies Septic shock business.industry Interleukin-6 CRITICALLY-ILL SEPTIC SHOCK Infant medicine.disease Survival Analysis Meningococcal Infections intestinal damage Enterocytes Gastric Mucosa meningococcal sepsis business Biomarkers Blood Chemical Analysis |
| Zdroj: | Critical Care Medicine, 38(1), 133-137. LIPPINCOTT WILLIAMS & WILKINS |
| ISSN: | 0090-3493 |
| Popis: | Objective: The pathophysiological sequelae of meningococcal sepsis are mainly caused by deregulated microvasculature function, leading to impaired tissue blood flow. Because mature enterocytes are known to be susceptible to altered perfusion, we aimed to investigate: (1) the development of enterocyte damage; and (2) the relation between enterocyte damage and severity of disease and outcome in children with meningococcal sepsis.Design: Retrospective human study.Setting: Pediatric intensive care unit at a university hospital.Patients: Nineteen consecutive children with meningococcal sepsis were studied during their pediatric intensive care unit stay.Interventions: None.Measurement and Main Results: Circulating levels of intestinal fatty acid binding protein, a small cytosolic protein constitutively present in mature enterocytes and released on cell injury, were assessed. Severity of disease was represented by meningococcal-specific Rotterdam Score, generic Pediatric Risk of Mortality II score, and circulating interleukin-6. Clinical outcome was measured by length of pediatric intensive care unit stay and number of ventilator days. Highest plasma intestinal fatty acid binding protein values were measured on pediatric intensive care unit stay admission. At the time of admission, eight of 19 patients had higher intestinal fatty acid binding protein plasma levels than the upper reference limit of 30 healthy volunteers. In all survivors, intestinal fatty acid binding protein levels declined to normal values within 12 hrs after starting intensive treatment, whereas the three nonsurvivors maintained elevated intestinal fatty acid binding protein plasma levels. A significant correlation was found among intestinal fatty acid binding protein and Rotterdam Score, Pediatric Risk of Mortality II, interleukin-6 at admission (Spearman's r(2) = 0.402, p =.006; r(2) = 0.243, p = .045; r(2) = 0.687, p Conclusions: Elevated plasma intestinal fatty acid binding protein is found in eight of 19 children with severe pediatric intensive care unit stay at the time of clinical presentation, suggesting the presence of enterocyte damage. Furthermore, prolonged enterocyte damage is found in nonsurvivors. Further studies are needed to clarify the potential role for assessment of plasma intestinal fatty acid binding protein in monitoring treatment of pediatric intensive care unit stay. (Crit Care Med 2010; 38:133-137) |
| Databáze: | OpenAIRE |
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