Molecular characteristics and virulence factors in methicillin-susceptible, resistant, and heterogeneous vancomycin-intermediate Staphylococcus aureus from central-southern China
| Autor: | Mingyue Sun, Ziyong Sun, Mingxiang Zou, Cai-lin Liu, Shanmei Wang, Yue Wang, Zhongju Chen, Wei Cao, Ji Zeng, Xianju Feng |
|---|---|
| Rok vydání: | 2015 |
| Předmět: |
Microbiology (medical)
China Staphylococcus aureus Genotype Virulence Factors Population Virulence Biology medicine.disease_cause Microbiology Immunology and Microbiology(all) Heterogeneous vancomycin-intermediate Staphylococcus aureus medicine Prevalence Humans Immunology and Allergy education Genotyping education.field_of_study General Immunology and Microbiology SCCmec Genetic Variation Molecular Hemolysin Vancomycin Resistance General Medicine Staphylococcal Infections biochemical phenomena metabolism and nutrition bacterial infections and mycoses Virology Methicillin-resistant Staphylococcus aureus Phenotype Infectious Diseases Virulence gene Exfoliatin Methicillin Resistance |
| Zdroj: | Journal of Microbiology, Immunology and Infection. 48(5):490-496 |
| ISSN: | 1684-1182 |
| DOI: | 10.1016/j.jmii.2014.03.003 |
| Popis: | BackgroundStaphylococcus aureus is a leading cause of nosocomial infections. The purpose of this study was to evaluate the prevalence of methicillin-resistant S. aureus (MRSA) and heterogeneous vancomycin-intermediate S. aureus (hVISA), and compare the antimicrobial susceptibility, molecular characteristic, and virulence factors in methicillin-susceptible S. aureus (MSSA), MRSA, and hVISA from central-southern China.MethodsA total of 184 S. aureus were isolated from sterile body fluids. All isolates were subjected to population analysis profiling for the identification of hVISA phenotype and polymerase chain reaction analysis for genotyping and 31 virulence genes.ResultsThe prevalence of MRSA isolates was 41.8% in central-southern China. Of 77 MRSA isolates, 17 (22.1%) were identified as hVISA. The most common MRSA and MSSA clones were ST239-MRSA-SCCmecIII-t030-agr-I (55.8%) and ST188-MSSA-t189-agr-I (20.6%), respectively. The frequency of carriage of pvl, hemolysins, tst, and staphylococcal enterotoxin genes among MSSA isolates was significantly higher than that for MRSA isolates (p |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|