Familial nephropathy in Bracchi Italiani: 8 cases (2012–2019)
| Autor: | Rachel E. Cianciolo, Amanda L. Inman, Ashley E. Allen-Durrance, Autumn N. Harris |
|---|---|
| Rok vydání: | 2021 |
| Předmět: |
medicine.medical_specialty
Proteinuria General Veterinary business.industry Amyloidosis Nephritis Hereditary medicine.disease Pedigree Nephropathy Dogs Glomerulopathy Internal medicine medicine Animals Clinical significance Dog Diseases medicine.symptom business Pathological Nephrosclerosis Retrospective Studies Kidney disease |
| Zdroj: | Journal of the American Veterinary Medical Association. 259:1422-1427 |
| ISSN: | 0003-1488 |
| Popis: | OBJECTIVE To characterize the signalment, clinical signs, clinical pathological and histologic findings, and outcome in 8 related Bracchi Italiani with proteinuric kidney disease. ANIMALS 8 client-owned Bracchi Italiani. PROCEDURES Health records submitted to the Bracco Italiano Health Foundation and the Bracco Italiano Club of America between 2012 and 2019 were reviewed for dogs with evidence of nephropathy for which histologic diagnoses were obtained. Pedigree, signalment, clinical signs, diagnostic test results (including microscopic examination of kidney tissue samples collected ante- or postmortem), and outcome were acquired. Results were presented as descriptive statistics. RESULTS The most common clinical sign in affected dogs was inappetence. All dogs were proteinuric, and 4 dogs were azotemic. Seven dogs developed clinical signs of kidney disease and were euthanized a median of 75 days postdiagnosis. Six dogs had glomerular amyloidosis, and 1 dog each had nephrosclerosis and nonamyloidotic fibrillar glomerulopathy. CONCLUSIONS AND CLINICAL RELEVANCE Results indicated that the clinical presentation may vary in affected dogs, and proteinuria in young or middle-aged Bracchi Italiani should raise the concern for hereditary nephropathy. Prognosis is likely poor once clinical signs are noted. |
| Databáze: | OpenAIRE |
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