Longitudinal Changes of PAI-1, MMP-2, and VEGF in Peritoneal Effluents and Their Associations with Peritoneal Small-Solute Transfer Rate in New Peritoneal Dialysis Patients

Autor: Mei-Chen Chao, Chien-Hsing Wu, Hong-Tao Yang, Jin-Bor Chen, Pei-Ling Liang, Na Hao, Terry Ting-Yu Chiou, Yang-Yang Lei
Rok vydání: 2019
Předmět:
Adult
Vascular Endothelial Growth Factor A
medicine.medical_specialty
Time Factors
Article Subject
medicine.medical_treatment
VEGF receptors
030232 urology & nephrology
Plasma creatinine
lcsh:Medicine
030204 cardiovascular system & hematology
Matrix metalloproteinase
Gastroenterology
General Biochemistry
Genetics and Molecular Biology
Peritoneal dialysis
03 medical and health sciences
chemistry.chemical_compound
0302 clinical medicine
Internal medicine
Plasminogen Activator Inhibitor 1
Medicine
Humans
Prospective Studies
Prospective cohort study
Aged
General Immunology and Microbiology
biology
business.industry
Plasminogen Activator Inhibitor Type 1
lcsh:R
General Medicine
Middle Aged
Vascular endothelial growth factor
chemistry
Creatinine
biology.protein
Matrix Metalloproteinase 2
business
Peritoneal Dialysis
Biomarkers
Cohort study
Research Article
Zdroj: BioMed Research International
BioMed Research International, Vol 2019 (2019)
ISSN: 2314-6141
Popis: Patients on peritoneal dialysis (PD) encounter peritoneal functional and structural alterations. It is still unknown whether levels of plasminogen activator inhibitor type 1 (PAI-1), matrix metalloproteinases- (MMP-) 2, and vascular endothelial growth factor (VEGF) exhibit dynamic changes in peritoneal effluents. The aim of the present study was to investigate the longitudinal changes in these biomarkers in PD patients and their association with peritoneal small-solute transfer rate (PSTR). This prospective, single-center cohort study included 70 new PD patients. The presence of PAI-1, MMP-2, and VEGF in peritoneal effluents was measured regularly after PD initiation. The association between those biomarkers and 4-hour effluent:plasma creatinine ratio (PSTR) was analyzed. Longitudinal follow-up showed a tendency for PAI-1 (p< 0.001) and VEGF (p= 0.04) to increase with the duration of PD. Both PSTR at baseline and PSTR at 2 years significantly associated with PAI-1, MMP-2, and VEGF levels at baseline. PSTR at 2 years also associated with the MMP-2 level at 6 months and PAI-1 level at baseline. The present study illustrated a positive association of PSTR with selected biomarkers in peritoneal effluents observed over a 2-year period.
Databáze: OpenAIRE
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