Longitudinal Changes of PAI-1, MMP-2, and VEGF in Peritoneal Effluents and Their Associations with Peritoneal Small-Solute Transfer Rate in New Peritoneal Dialysis Patients
Autor: | Mei-Chen Chao, Chien-Hsing Wu, Hong-Tao Yang, Jin-Bor Chen, Pei-Ling Liang, Na Hao, Terry Ting-Yu Chiou, Yang-Yang Lei |
---|---|
Rok vydání: | 2019 |
Předmět: |
Adult
Vascular Endothelial Growth Factor A medicine.medical_specialty Time Factors Article Subject medicine.medical_treatment VEGF receptors 030232 urology & nephrology Plasma creatinine lcsh:Medicine 030204 cardiovascular system & hematology Matrix metalloproteinase Gastroenterology General Biochemistry Genetics and Molecular Biology Peritoneal dialysis 03 medical and health sciences chemistry.chemical_compound 0302 clinical medicine Internal medicine Plasminogen Activator Inhibitor 1 Medicine Humans Prospective Studies Prospective cohort study Aged General Immunology and Microbiology biology business.industry Plasminogen Activator Inhibitor Type 1 lcsh:R General Medicine Middle Aged Vascular endothelial growth factor chemistry Creatinine biology.protein Matrix Metalloproteinase 2 business Peritoneal Dialysis Biomarkers Cohort study Research Article |
Zdroj: | BioMed Research International BioMed Research International, Vol 2019 (2019) |
ISSN: | 2314-6141 |
Popis: | Patients on peritoneal dialysis (PD) encounter peritoneal functional and structural alterations. It is still unknown whether levels of plasminogen activator inhibitor type 1 (PAI-1), matrix metalloproteinases- (MMP-) 2, and vascular endothelial growth factor (VEGF) exhibit dynamic changes in peritoneal effluents. The aim of the present study was to investigate the longitudinal changes in these biomarkers in PD patients and their association with peritoneal small-solute transfer rate (PSTR). This prospective, single-center cohort study included 70 new PD patients. The presence of PAI-1, MMP-2, and VEGF in peritoneal effluents was measured regularly after PD initiation. The association between those biomarkers and 4-hour effluent:plasma creatinine ratio (PSTR) was analyzed. Longitudinal follow-up showed a tendency for PAI-1 (p< 0.001) and VEGF (p= 0.04) to increase with the duration of PD. Both PSTR at baseline and PSTR at 2 years significantly associated with PAI-1, MMP-2, and VEGF levels at baseline. PSTR at 2 years also associated with the MMP-2 level at 6 months and PAI-1 level at baseline. The present study illustrated a positive association of PSTR with selected biomarkers in peritoneal effluents observed over a 2-year period. |
Databáze: | OpenAIRE |
Externí odkaz: |