Local C-Reactive Protein Expression in Obliterative Lesions and the Bronchial Wall in Posttransplant Obliterative Bronchiolitis
| Autor: | Pekka J. Karhunen, Hanni S Alho, Tiina Vainikka, Outi E. Päiväniemi, Paula Maasilta, Ulla-Stina Salminen |
|---|---|
| Přispěvatelé: | University of Tampere |
| Jazyk: | angličtina |
| Rok vydání: | 2009 |
| Předmět: |
Pathology
medicine.medical_specialty Article Subject Swine Immunology Bronchi Transplantation Autologous Proinflammatory cytokine Immune system lcsh:Pathology medicine Animals Transplantation Homologous Respiratory system Bronchiolitis Obliterans Sisätaudit - Internal Medicine Bronchus biology business.industry C-reactive protein Acute-phase protein Cell Biology Immunohistochemistry Transplantation C-Reactive Protein medicine.anatomical_structure Gene Expression Regulation biology.protein business CD8 lcsh:RB1-214 Research Article |
| Zdroj: | Mediators of Inflammation Mediators of Inflammation, Vol 2009 (2009) |
| ISSN: | 0962-9351 |
| DOI: | 10.1155/2009/510254 |
| Popis: | The local immunoreactivity of C-reactive protein (CRP) was studied in a heterotopic porcine model of posttranplant obliterative bronchiolitis (OB). Bronchial allografts and control autografts were examined serially 2–28 days after subcutaneous transplantation. The autografts stayed patent. In the allografts, proliferation of inflammatory cells (P<.0001) and fibroblasts (P=.02) resulted in occlusion of the bronchial lumens (P<.01). Influx of CD4+ (P<.001) and CD8+ (P<.0001) cells demonstrated allograft immune response. CRP positivity simultaneously increased in the bronchial walls (P<.01), in macrophages, myofibroblasts, and endothelial cells. Local CRP was predictive of features characteristic of OB (R=0.456–0.879,P<.05−P<.0001). Early obliterative lesions also showed CRP positivity, but not mature, collagen-rich obliterative plugs (P<.05). During OB development, CRP is localized in inflammatory cells, myofibroblasts and endothelial cells probably as a part of the local inflammatory response. |
| Databáze: | OpenAIRE |
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