Levels of intracellular HIV-DNA in patients with suppressive antiretroviral therapy
| Autor: | Lise, Cuzin, Pascal, Pugliese, Karine, Sauné, Clotilde, Allavena, Jade, Ghosn, Jacqueline, Cottalorda, Audrey, Rodallec, Marie Laure, Chaix, Samira, Fafi-Kremer, Cathia, Soulié, Marlène, Ouka, Charlotte, Charpentier, Laurence, Bocket, Audrey, Mirand, Marguerite, Guiguet, S, Casanova |
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| Přispěvatelé: | Hôpital Purpan, CHU Toulouse [Toulouse], Laboratory of Virology, Toulouse University hospital, Service de maladies infectieuses et tropicales [Nantes], Université de Nantes (UN)-Hôtel-Dieu-Centre hospitalier universitaire de Nantes (CHU Nantes), Laboratoire de Virologie [CHU Necker], Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-CHU Necker - Enfants Malades [AP-HP], CHU Necker - Enfants Malades [AP-HP], Université Paris Descartes - Paris 5 (UPD5), Infection à VIH, réservoirs, diversité génétique et résistance aux antirétroviraux (ARV) (EA 7327), Université Sorbonne Paris Cité (USPC), Ecosystèmes Côtiers Marins et Réponses aux Stress (ECOMERS), Université Nice Sophia Antipolis (... - 2019) (UNS), Université Côte d'Azur (UCA)-Université Côte d'Azur (UCA), Service de virologie [CHU Nantes], Centre hospitalier universitaire de Nantes (CHU Nantes), Infections à Vih, Réservoirs, Pharmacologie des Antirétroviraux et Prévention de la Transmission Mère Enfant, Interaction virus-hôte et maladies du foie, Université de Strasbourg (UNISTRA)-Institut National de la Santé et de la Recherche Médicale (INSERM), Epidémiologie, stratégies thérapeutiques et virologie cliniques dans l'infection à VIH, Université Pierre et Marie Curie - Paris 6 (UPMC)-Institut National de la Santé et de la Recherche Médicale (INSERM), Laboratoire de Virologie, Assistance publique - Hôpitaux de Paris (AP-HP) (APHP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Laboratoire de virologie [CHU Lille], Centre Hospitalier Régional Universitaire [Lille] (CHRU Lille), Laboratoire Microorganismes : Génome et Environnement - Clermont Auvergne (LMGE), Université Clermont Auvergne (UCA)-Centre National de la Recherche Scientifique (CNRS), Institut Pierre Louis d'Epidémiologie et de Santé Publique (iPLESP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP), COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-COMUE Université Côte d'Azur (2015-2019) (COMUE UCA)-Université Côte d'Azur (UCA), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-AP-HP - Hôpital Bichat - Claude Bernard [Paris], Laboratoire Microorganismes : Génome et Environnement (LMGE), Centre National de la Recherche Scientifique (CNRS)-Université Clermont Auvergne [2017-2020] (UCA [2017-2020]), Institut National de la Santé et de la Recherche Médicale (INSERM)-Université Pierre et Marie Curie - Paris 6 (UPMC), Centre Hospitalier Universitaire de Toulouse (CHU Toulouse), Assistance publique - Hôpitaux de Paris (AP-HP) (AP-HP)-CHU Necker - Enfants Malades [AP-HP], Université Nice Sophia Antipolis (1965 - 2019) (UNS), Université Clermont Auvergne [2017-2020] (UCA [2017-2020])-Centre National de la Recherche Scientifique (CNRS) |
| Rok vydání: | 2015 |
| Předmět: |
Adult
Male medicine.medical_specialty Cross-sectional study Immunology HIV Infections [SDV.MP.PRO]Life Sciences [q-bio]/Microbiology and Parasitology/Protistology 03 medical and health sciences 0302 clinical medicine Interquartile range Internal medicine medicine Humans Immunology and Allergy In patient 030212 general & internal medicine Viral suppression Cd4 cell count ComputingMilieux_MISCELLANEOUS 030304 developmental biology 0303 health sciences business.industry Middle Aged Viral Load [SDV.MP.BAC]Life Sciences [q-bio]/Microbiology and Parasitology/Bacteriology Antiretroviral therapy CD4 Lymphocyte Count 3. Good health Cross-Sectional Studies Infectious Diseases Increased risk Anti-Retroviral Agents DNA Viral Female business Viral load |
| Zdroj: | AIDS AIDS, Lippincott, Williams & Wilkins, 2015, 29 (13), pp.1665-1671. ⟨10.1097/QAD.0000000000000723⟩ AIDS. Official journal of the international AIDS Society AIDS. Official journal of the international AIDS Society, 2015, 29 (13), pp.1665-1671. ⟨10.1097/QAD.0000000000000723⟩ |
| ISSN: | 0269-9370 1473-5571 |
| Popis: | OBJECTIVE The objective of this study is to study factors associated with HIV-DNA levels in chronically infected patients on long-term suppressive antiretroviral therapy (ART). DESIGN A cross-sectional, multicentre study of patients receiving ART for more than 3 years, HIV-RNA less than 50 copies/ml for more than 2 years and CD4 cell count more than 350 cells/μl. METHOD Factors associated with low ( 1000), compared with intermediate (150-1000 copies/10 PBMCs) levels of HIV-DNA were investigated using multinomial logistic regression. RESULTS Five hundred and twenty-two patients who initiated ART during the chronic phase were included (71% male; median peak HIV-RNA: 4.88 log10 copies/ml, CD4 cell count nadir: 222 cells/μl). Median ART duration was 13 years [interquartile range (IQR) 7-17], viral suppression was 5.7 years (IQR 3.9-8.5) and 66% of the patients never experienced ART failure. Median HIV-DNA was 323 copies/10 PBMCs (IQR, 129-717) with low, intermediate and high levels observed in 28.3, 55.4 and 16.3%, respectively. In multivariable analysis, women were more likely to achieve a low level of HIV-DNA. Each additional year with suppressed HIV-RNA increased the likelihood of low level and decreased the likelihood of high level of HIV-DNA. Peak HIV-RNA higher than 5log10 was always associated with a decreased risk of low and an increased risk of high HIV-DNA. For patients with peak HIV-RNA lower than 5log10, past ART failure was associated with high level of HIV-DNA. CONCLUSION Chronically HIV-infected patients with long-term suppressive ART can achieve low total HIV-DNA but one over six still presented HIV-DNA above 1000 copies/10 PBMCs despite long-term viral suppression. |
| Databáze: | OpenAIRE |
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