Appropriate Number of Adjuvant Chemotherapy Cycles for Patients with Stage 2 or 3 Gastric Cancer After Curative Gastrectomy: A Multicenter Cohort Study
| Autor: | Joong-Min Park, Sung Il Choi, Sung Soo Kim, Moon Soo Lee, Kyung Won Seo, Hyoung Il Kim, Myoung Won Son, Sang Eok Lee, Jae-Seok Min, Ye Seob Jee, Han Hong Lee, Moon-Won Yoo, Sun-Hwi Hwang, In Ho Jeong, Hoon Hur, Hyundong Chae, Sung Jin Oh, Chang-Hyun Kim, Sungsoo Park, Sungho Jin, Chang Min Lee, Chan Young Kim, Sang-Il Lee, Sang-Ho Jeong, Kyung Ho Pak, Yong-Joon Lee, Jong-Han Kim, Young-Gil Son |
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| Rok vydání: | 2020 |
| Předmět: |
medicine.medical_specialty
medicine.medical_treatment Gastroenterology Disease-Free Survival Cohort Studies 03 medical and health sciences 0302 clinical medicine Surgical oncology Gastrectomy Stomach Neoplasms Internal medicine Antineoplastic Combined Chemotherapy Protocols Republic of Korea medicine Humans Stage (cooking) Neoplasm Staging Retrospective Studies business.industry Proportional hazards model Hazard ratio Cancer medicine.disease Confidence interval Oncology Chemotherapy Adjuvant 030220 oncology & carcinogenesis 030211 gastroenterology & hepatology Surgery business Adjuvant Cohort study |
| Zdroj: | Annals of surgical oncology. 28(8) |
| ISSN: | 1534-4681 |
| Popis: | Few studies have presented evidence pertaining to the adequate minimum number of adjuvant chemotherapy (AC) cycles required to achieve an oncologic benefit for gastric cancer. From January 2012 to December 2013, data from patients who underwent curative radical gastrectomy and consequently received AC for pathologic stage 2 or 3 gastric cancer at 27 institutions in South Korea were analyzed. The study enrolled 925 patients, 661 patients (71.5%) who completed 8 cycles of AC and 264 patients (28.5%) who did not. Compared with the mean disease-free survival (DFS) of the patients who completed 8 AC cycles (69.3 months), the mean DFS of patients who completed 6 AC cycles (72.4 months; p = 0.531) and those who completed 7 AC cycles (63.7 months; p = 0.184) did not differ significantly. However, the mean DFS of the patients who completed 5 AC cycles (48.2 months; p = 0.016) and those who completed 1–4 AC cycles (62.9 months; p = 0.036) was significantly lower than the DFS of those who completed 8 AC cycles. In the multivariate Cox proportional hazards analysis, the mean DFS was significantly affected by advanced stage, large tumor size, positive vascular invasion, and number of completed AC cycles (1–5 cycles: hazard ratio 1.45; 95% confidence interval 1.01–2.08; p = 0.041). The current multicenter observational cohort study showed that the mean DFS for 6 or 7 AC cycles was similar to that for 8 AC cycles as an adjuvant treatment for gastric cancer. |
| Databáze: | OpenAIRE |
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