Preliminary Proteomic Analysis of A549 Cells Infected with Avian Influenza Virus H7N9 and Influenza A Virus H1N1

Autor:	Jiahai Lu, Ruoxi Yu, Xiaoman Ding, Jinquan Cheng, Renli Zhang, Weihua Wu, Yijie Geng, Shisong Fang, Xin Wang, Ting Wang, Hui Liu, Hanwu Ma, Bo Peng, Muhua Yu, Fangyuan Dong
Jazyk:	angličtina
Rok vydání:	2016
Předmět:	0301 basic medicine RNA viruses Proteomics Proteome Pulmonology Protein Expression lcsh:Medicine medicine.disease_cause Influenza A Virus H7N9 Subtype Biochemistry Influenza A Virus H1N1 Subtype Cytopathogenic Effect Viral Influenza A virus lcsh:Science Pathology and laboratory medicine Cytopathic effect Extracellular Matrix Proteins Multidisciplinary Medical microbiology Viruses Protein Interaction Networks Pathogens Network Analysis Research Article Computer and Information Sciences Ornithine aminotransferase Biology Research and Analysis Methods Microbiology Virus H7N9 03 medical and health sciences Eukaryotic translation VP40 Influenza Human DNA-binding proteins medicine Gene Expression and Vector Techniques Initiation factor Humans Influenza viruses Molecular Biology Techniques Molecular Biology A549 cell Medicine and health sciences Molecular Biology Assays and Analysis Techniques Biology and life sciences lcsh:R Organisms Viral pathogens Proteins Virology Microbial pathogens Cytoskeletal Proteins 030104 developmental biology Gene Expression Regulation A549 Cells Respiratory Infections lcsh:Q Orthomyxoviruses
Zdroj:	PLoS ONE, Vol 11, Iss 5, p e0156017 (2016) PLoS ONE
ISSN:	1932-6203
Popis:	A newly emerged H7N9 influenza virus poses high risk to human beings. However, the pathogenic mechanism of the virus remains unclear. The temporal response of primary human alveolar adenocarcinoma epithelial cells (A549) infected with H7N9 influenza virus and H1N1 influenza A virus (H1N1, pdm09) were evaluated using the proteomics approaches (2D-DIGE combined with MALDI-TOF-MS/MS) at 24, 48 and 72 hours post of the infection (hpi). There were 11, 12 and 33 proteins with significant different expressions (P
Databáze:	OpenAIRE
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