Pilot study to evaluate a plasma device for the treatment of onychomycosis
| Autor: | Gary Friedman, Richard K. Scher, Shari R. Lipner |
|---|---|
| Rok vydání: | 2017 |
| Předmět: |
Adult
Male 0301 basic medicine medicine.medical_specialty Plasma Gases 030106 microbiology Pilot Projects Dermatology Trichophyton rubrum 030207 dermatology & venereal diseases 03 medical and health sciences 0302 clinical medicine Patient satisfaction Secondary outcome Tinea Trichophyton Candida albicans Onychomycosis Clinical endpoint Humans Medicine Clinical efficacy skin and connective tissue diseases Adverse effect Aged Foot Dermatoses biology business.industry Candidiasis Middle Aged biology.organism_classification Patient Satisfaction Female business In vitro growth |
| Zdroj: | Clinical and Experimental Dermatology. 42:295-298 |
| ISSN: | 0307-6938 |
| DOI: | 10.1111/ced.12973 |
| Popis: | Onychomycosis is a fungal infection of the nail unit, and is the most common of the nail disorders. Current therapies for onychomycosis have less than ideal efficacy and have the potential for adverse effects. As previous studies have shown that nonthermal plasma inhibits the in vitro growth of Trichophyton rubrum, we conducted a pilot study on 19 participants with toenail onychomycosis. The primary endpoint was safety of the device, and secondary outcome measures were clinical efficacy and mycological cure. Patient satisfaction was measured using questionnaires at the completion of the study. All but one patient met the primary endpoint of safety and there were no long-term sequelae. The overall clinical cure was 53.8% and the mycological cure was 15.4%. The majority of patients were satisfied with the treatment. Our conclusions are that nonthermal plasma is a safe treatment and may have a beneficial effect on toenail onychomycosis. |
| Databáze: | OpenAIRE |
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