Renal functional reserve in calcium channel blocker-treated hypertensive recipients of kidney transplant
| Autor: | J. J. Lloveras, Lionel Rostaing, Ivan Tack, T. Tran-Van, J. M. Suc, J. L. Ader, Dominique Durand |
|---|---|
| Rok vydání: | 1995 |
| Předmět: |
Adult
Male medicine.medical_specialty Hypertension Renal Renal Plasma Flow Lithium (medication) Nifedipine medicine.drug_class Renal function Calcium channel blocker urologic and male genital diseases Internal medicine medicine Humans Amino Acids Retrospective Studies Transplantation Kidney Voltage-dependent calcium channel business.industry Calcium channel Nitrendipine Middle Aged Calcium Channel Blockers Kidney Transplantation medicine.anatomical_structure Endocrinology Nephrology Cyclosporine Female Isradipine business Glomerular hyperfiltration medicine.drug Glomerular Filtration Rate |
| Zdroj: | Nephrology, dialysis, transplantation : official publication of the European Dialysis and Transplant Association - European Renal Association. 10 |
| ISSN: | 0931-0509 |
| Popis: | Renal functional reserve during infusion of an amino acid solution was examined in 12 cyclosporin-treated kidney recipients at 1 (T1) and 8 months (T2) after transplantation. Patients were retrospectively divided into six normotensive (NT) and six hypertensive recipients (HT) maintained on monotherapy with a calcium channel blocker. Baseline glomerular filtration rates (GFR) were similar in NT and HT at T1 and T2. Renal functional reserve was identical in NT and HT at T1 (15 +/- 7 vs 18 +/- 13 ml/min/1.73 m2) but significantly greater in HT at T2 (11 +/- 5 vs 23 +/- 10 ml/min/1.73 m2; P < 0.05). At T2, baseline proximal tubule outflow (lithium clearance) was greater in HT (26 +/- 8 vs 16 +/- 3 ml/min/1.73 m2; P < 0.05), whereas fractional proximal reabsorption was less (54 +/- 11% vs 67 +/- 5%; P < 0.05). These results indicate that: (i) hypertensive recipients on calcium channel blocker therapy do not exhibit permanent glomerular hyperfiltration until 8 months after transplantation, and have a reduced proximal reabsorption; (ii) measurement of amino acid-stimulated GFR and renal functional reserve is a more sensitive method than that of baseline GFR for evaluating renal function and the effects of therapy in kidney recipients. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|