Vasomotor effects of transcutaneous CO2 in stage II peripheral occlusive arterial disease
| Autor: | Olivier Bailliart, Jean Coudert, Philippe Bonnin, Mario Bedu, E. Savin, J.P. Martineaud, Jean Cheynel |
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| Předmět: |
Male
Percutaneous Rest Hemodynamics Arterial Occlusive Diseases 030204 cardiovascular system & hematology Administration Cutaneous 03 medical and health sciences 0302 clinical medicine Double-Blind Method medicine.artery Heart rate Medicine Humans 030212 general & internal medicine Aged Leg Vasomotor business.industry Vascular disease Baths Blood flow Carbon Dioxide Middle Aged medicine.disease Peripheral Vasomotor System Posterior tibial artery Anesthesia Cardiology and Cardiovascular Medicine business Blood Gas Monitoring Transcutaneous |
| Zdroj: | Europe PubMed Central |
| Popis: | Vasomotor effects of skin exposure to carbon dioxide (CO2) have been described in normal subjects. It was of interest, therefore, to determine whether percutaneous CO2 is of therapeutic benefit. In a randomized, double-blind study, 10 patients with lower limb arteriopathy (stage II) were investigated before and after local exposure for twenty minutes to CO2-rich spa gas or to water-vapor-saturated air at the same temperature as that CO2 -rich spa gas. Brachial and femoral blood flows, brachial and posterior tibial artery pressures, heart rate, and chest and foot transcutaneous oxygen tensions (tcPO2) were determined. Femoral blood flow, tibial pressure, and foot tcPO2 were significantly increased after exposure of the skin to CO2-rich spa gas. This effect was not accompanied with systemic hemodynamic modifications. Water-vapor-saturated air had no effect. These results suggest that transfer of CO2 across the skin can have beneficial local vasomotor effects in patients with lower limb stage II arteriopathy. |
| Databáze: | OpenAIRE |
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