Studies of microsomal glucose-6-phosphatase on liver of irradiated rats
| Autor: | Bernard P, Drouet J, Rocquet G, Neveux Y |
|---|---|
| Rok vydání: | 1980 |
| Předmět: |
Male
medicine.medical_specialty Time Factors Cysteamine Biochemistry chemistry.chemical_compound In vivo Internal medicine medicine Animals Irradiation chemistry.chemical_classification biology Chemistry Acute Radiation Syndrome Enzyme assay Rats Endocrinology Enzyme Liver Gamma Rays Microsome biology.protein Glucose-6-Phosphatase Microsomes Liver Glucose 6-phosphatase |
| Zdroj: | Enzyme. 25(4) |
| ISSN: | 0013-9432 |
| Popis: | The activity of microsomal glucose-6-phosphatase (EC 3.1.3.9) on male rat liver was measured 1-9 days after whole-body gamma-irradiation. A marked fall of activity, expressed per whole liver, was observed reaching a minimum on the 4th day following irradiation. The enzyme activity is partially and momentarily restored (on day 7), before a new decrease occurred. Furthermore, when the results are expressed per milligram of microsomal proteins, there was no change. Cysteamine, when injected in vivo, kept up the glucose-6-phosphatase of whole liver. On day 4, a histochemical demonstration of the enzyme in liver cells is in accordance with enzyme measures. These observations suggested that the enzyme quantity was altered during the acute radiation syndrome in the rat. |
| Databáze: | OpenAIRE |
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