Molecular surveillance of pandemic influenza A(H1N1) viruses circulating in Italy from May 2009 to February 2010: association between haemagglutinin mutations and clinical outcome
| Autor: | Puzelli, S, Facchini, M, De Marco, M. A, Palmieri, A, Spagnolo, D, Boros, S, Corcioli, F, Trotta, D, Bagnarelli, P, Azzi, Anna, Cassone, A, Rezza, G, Pompa, M. G, Oleari, F, Donatelli, I, Capobianchi, Mr, Fadda, Giuseppe, Palu', Giorgio, Vitale, F, D'Agaro, P, Esposito, C, Ghisetti, V, Ansaldi, F, Zanetti, A, Nelli, Lc, Baldanti, F. |
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| Přispěvatelé: | Puzelli, S., Facchini, M., De Marco, M. A., Palmieri, A., Spagnolo, D., Boros, S., Corcioli, F., Trotta, D., Bagnarelli, P., Azzi, A., Cassone, A., Rezza, G., Pompa, M. G., Oleari, F., Donatelli, I., Influnet Surveillance Group for Pandemic A., 2009 Influenza Virus in Italy, D'Agaro, Pierlanfranco, Puzelli, S, Facchini, M, De Marco, MA, Palmieri, A, Spagnolo, D, Boros, S, Corcioli, F, Trotta, D, Bagnarelli, P, Azzi, A, Cassone, A, Rezza, G, Pompa, MG, Oleari, F, Donatelli, I, Vitale, F |
| Rok vydání: | 2010 |
| Předmět: |
Male
Molecular surveillance Pandemic influenza A(H1N1) Haemagglutinin mutations Italy from May 2009 to February 2010 pandemic influenza surveillance of pandemic influenza A(H1N1) Epidemiology viruses Settore MED/42 - Igiene Generale E Applicata medicine.disease_cause Severity of Illness Index Influenza A Virus H1N1 Subtype Pandemic Influenza A Virus A(H1N1) Child Mutation Reverse Transcriptase Polymerase Chain Reaction Transmission (medicine) Adolescent Adult Age Distribution Aged Amino Acid Substitution Child Preschool Female Hemagglutinins Humans Infant Influenza Human Italy Middle Aged Population Surveillance Sex Distribution Young Adult Pandemics haemagglutinin mutations Human Biology Disease cluster Disease course Virology medicine H1N1 Subtype Preschool Molecular epidemiology Public Health Environmental and Occupational Health Pandemic influenza Influenza Mutational analysis |
| Zdroj: | Eurosurveillance. 15 |
| ISSN: | 1560-7917 |
| Popis: | Haemagglutinin sequences of pandemic influenza A(H1N1) viruses circulating in Italy were examined, focusing on amino acid changes at position 222 because of its suggested pathogenic relevance. Among 169 patients, the D222G substitution was detected in three of 52 (5.8%) severe cases and in one of 117 (0.9%) mild cases, whereas the D222E mutation was more frequent and evenly distributed in mild (31.6%) and severe cases (38.4%). A cluster of D222E viruses among school children confirms reported human-to-human transmission of viruses mutated at amino acid position 222. |
| Databáze: | OpenAIRE |
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