Association of HER1 amplification with poor prognosis in well differentiated gastric carcinomas
| Autor: | Jean-François Mosnier, Christine Kandel, Christian L. Laboisse, Chantal Bou-Hanna, François Leclair |
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| Rok vydání: | 2013 |
| Předmět: |
Adult
Male Pathology medicine.medical_specialty Poor prognosis Receptor ErbB-2 Biology HercepTest Pathology and Forensic Medicine Stomach Neoplasms Pancreatic cancer Biomarkers Tumor medicine Humans In Situ Hybridization Fluorescence Aged Proportional Hazards Models Aged 80 and over Univariate analysis Carcinoma General Medicine Middle Aged Cadherins Prognosis medicine.disease Immunohistochemistry Well differentiated ErbB Receptors Tissue Array Analysis In situ hybridisation Female Histopathology France Immunostaining Follow-Up Studies |
| Zdroj: | Journal of Clinical Pathology. 67:307-312 |
| ISSN: | 1472-4146 0021-9746 |
| Popis: | Aims The pattern of E-cadherin expression and the HER1/HER2 status were studied in European patients with gastric carcinomas in relation with their differentiation and prognosis. Methods 82 gastric carcinomas (five papillary, 52 tubular, 19 poorly cohesive and six mixed according to WHO classification) were investigated for E-cadherin distribution (normal: restricted to the membrane; abnormal: absent or cytoplasmic expression), HER1 and HER2 expression using HercepTest and amplification using fluorescent in situ hybridisation. Statistical analysis assessed the association between the markers and their correlation with clinicopathological parameters and follow-up information. Results Abnormal E-cadherin distribution was found in 34 of the 82 gastric carcinomas (41%) (18/25 poorly cohesive or mixed (72%); 16/57 papillary or tubular type (28%)). HER1 overexpression (3+) and equivocal expression (2+) were found in five carcinomas (6%; four tubular and one poorly cohesive) and eight carcinomas (10%; six tubular and two poorly cohesive), respectively. HER2 overexpression (3+) and equivocal expression (2+) were found in seven carcinomas (8%; five papillary and two tubular) and three carcinomas (4%; three tubular), respectively. Amplification of HER1 or HER2 was detected in 14 gastric carcinomas (five papillary and nine tubular). All of them showed a normal E-cadherin distribution. In the univariate analysis, only HER1 amplification had a prognostic impact, while HER2 amplification and E-cadherin expression/distribution were not per se prognostically relevant. Conclusions E-cadherin immunostaining and HER1 in situ hybridisation define a group of well differentiated gastric carcinomas with poor prognosis eligible for an aggressive therapeutic approach. |
| Databáze: | OpenAIRE |
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