Progression of acromegalic arthropathy in long-term controlled acromegaly patients: 9 years of longitudinal follow-up
| Autor: | Alberto M. Pereira, Kim M J A Claessen, Wouter R van Furth, Nienke R. Biermasz, Herman M. Kroon, Iris C. M. Pelsma, Margreet Kloppenburg |
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| Přispěvatelé: | Internal medicine |
| Rok vydání: | 2020 |
| Předmět: |
Male
musculoskeletal diseases medicine.medical_specialty Endocrinology Diabetes and Metabolism Radiography Clinical Biochemistry 030209 endocrinology & metabolism Context (language use) Osteoarthritis Biochemistry longitudinal follow-up study Cohort Studies 03 medical and health sciences 0302 clinical medicine Endocrinology Internal medicine Arthropathy Acromegaly medicine Humans In patient Longitudinal Studies Aged Netherlands 030203 arthritis & rheumatology business.industry Remission Induction Biochemistry (medical) Acromegalic Arthropathy Middle Aged medicine.disease insulin-like growth factor-1 osteoarthritis growth hormone Disease Progression acromegaly Female Lumbar spine Joint Diseases business Biomarkers arthropathy Follow-Up Studies |
| Zdroj: | Journal of Clinical Endocrinology and Metabolism, 106(1), 188-200. ENDOCRINE SOC Pelsma, I C M, Biermasz, N R, van Furth, W R, Pereira, A M, Kroon, H M, Kloppenburg, M & Claessen, K M J A 2021, ' Progression of acromegalic arthropathy in long-term controlled acromegaly patients: 9 years of longitudinal follow-up ', Journal of Clinical Endocrinology and Metabolism, vol. 106, no. 1, pp. 188-200 . https://doi.org/10.1210/clinem/dgaa747 Journal of Clinical Endocrinology and Metabolism, 106(1), 188-200. The Endocrine Society |
| ISSN: | 1945-7197 0021-972X |
| DOI: | 10.1210/clinem/dgaa747 |
| Popis: | Context Joint complaints in patients with acromegaly are common, although the long-term disease course is largely unknown. Objective This study aims to evaluate the long-term course of acromegalic arthropathy. Design and Setting A prospective longitudinal cohort study was conducted in controlled acromegaly patients followed at a tertial referral center, with 3 study visits: at baseline and after a median of 2.6 and 9.1 years. Patients We included 31 patients with biochemically controlled acromegaly for 2 or more years (49% female; median age, 60 years) at baseline. Main Outcome Measures Radiographic arthropathy of the knee, hip, hand, and cervical and lumbar spine were evaluated using Kellgren and Lawrence (KL) scores, developed for assessment of primary osteoarthritis (OA). Radiographic progression was defined as a KL increase above the smallest detectable change. Joint symptoms were assessed using self-reported questionnaires. Progression was defined using existing clinically important cutoff values. Risk factors for progression were investigated using a multivariable model. Results All patients had definite radiographic OA at 1 or more joints at baseline. Radiographic progression was observed in 29%, 48%, 84%, and 94% of patients in the knees, hips, hands, and axial joints, respectively. Deterioration in hand-related pain and function was observed in 10 (32.3%) and 11 patients (35.5%), respectively. Solely baseline KL scores of the hip were associated with hip OA progression (OR 1.88; 95% CI, 1.09-3.16). Conclusions Acromegalic arthropathy showed significant radiographic progression over 9.1 years of follow-up in patients in remission, whereas clinical progression was observed less frequently. Future studies should focus on adequate prevention and treatment strategies of acromegalic arthropathy. |
| Databáze: | OpenAIRE |
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