Cell division orientation on biospecific peptide gradients
| Autor: | Brian M. Lamb, Muhammad N. Yousaf, Sarbajeet Nagdas, Wei Luo |
|---|---|
| Rok vydání: | 2014 |
| Předmět: |
Materials science
Cell division Cell Cell Polarity Cell migration Nanotechnology Division (mathematics) Fibroblasts Ligand (biochemistry) Small molecule Cell Line Extracellular Matrix Rats Extracellular matrix medicine.anatomical_structure Cell Movement Cell polarity Biophysics medicine Cell Adhesion Animals General Materials Science Peptides Cell Division |
| Zdroj: | ACS applied materialsinterfaces. 6(14) |
| ISSN: | 1944-8252 |
| Popis: | An assay was developed for determining cell division orientation on gradients. The methodology is based on permeating microfluidic devices with alkanethiols and subsequent printing of cell adhesive peptide gradient self-assembled monolayers (SAMs) for examining oriented cell divisions. To our knowledge, there has been no study examining the correlation between cell division orientations based on an underlying ligand gradient. These results implicate an important role for how the extracellular matrix may control cell division. These surfaces would allow for a range of cell behavior (polarization, migration, division, differentiation) studies on tailored biospecific gradients and as a potential biotechnological platform to assess small molecule perturbations of cell function. |
| Databáze: | OpenAIRE |
| Externí odkaz: |
|